Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, PR China.
Tianjin University of Traditional Chinese Medicine, Jian Kang Chan Ye Yuan, Jinghai District, Tianjin, PR China.
Biosci Rep. 2020 Nov 27;40(11). doi: 10.1042/BSR20201747.
The prevalence of hypertension has increased rapidly in recent years. Currently, increasing attention has been paid to the relationship between hypertension and platelet abnormalities. As a simple and available platelet parameter, platelet distribution width (PDW) can reflect platelet abnormalities and further reflect the risk of thrombotic diseases. However, the views on PDW and hypertension are controversial at present studies. Hence, we aimed to find the associations between PDW and hypertension subtypes in the present study. A total of 73,469 participants (44,665 males and 28,804 females) were enrolled. We found that PDW was a risk factor for isolated systolic hypertension (ISH), and the risk of ISH increased with PDW quartiles among women. In men, high PDW might be a risk factor for isolated diastolic hypertension and systolic-diastolic hypertension.
近年来，高血压的患病率迅速上升。目前，人们越来越关注高血压与血小板异常之间的关系。血小板分布宽度（PDW）作为一种简单、可用的血小板参数，可反映血小板异常，并进一步反映血栓性疾病的风险。然而，目前的研究对 PDW 和高血压的观点存在争议。因此，本研究旨在探讨 PDW 与高血压亚型之间的关系。共纳入 73469 名参与者（男性 44665 名，女性 28804 名）。结果发现，PDW 是单纯收缩期高血压（ISH）的危险因素，且女性中随着 PDW 四分位数的升高，ISH 的发病风险也随之增加。在男性中，高 PDW 可能是单纯舒张期高血压和收缩期-舒张期高血压的危险因素。
