Matti Penttilä, MD, PhD, University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, and Oulu University Hospital, Oulu; Erika Jääskeläinen, MD, PhD, University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, and Institute of Health Sciences, and Oulu University Hospital, and Medical Research Center Oulu; Noora Hirvonen, MSc, University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, and Faculty of Humanities, Information Studies, Oulu; Matti Isohanni, MD, PhD, University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, and Oulu University Hospital, Oulu; Jouko Miettunen, PhD, University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, and Institute of Health Sciences, and Oulu University Hospital, and Medical Research Center Oulu, Finland.
Br J Psychiatry. 2014 Aug;205(2):88-94. doi: 10.1192/bjp.bp.113.127753. Epub 2014 Aug 1.
Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear.
To analyse the associations between DUP and long-term outcomes of schizophrenia.
A systematic literature search was performed using seven electronic databases and manual searches. Random effects weighted meta-analysis with correlation coefficients was used to pool the results.
We identified 3493 unique publications, from which 33 samples met our predefined selection criteria. Long DUP correlated statistically significantly with poor general symptomatic outcome, more severe positive and negative symptoms, lesser likelihood of remission and poor social functioning and global outcome (correlations 0.13-0.18). Long DUP was not associated with employment, quality of life or hospital treatment.
The small but mostly consistent correlation between long DUP and poor outcome indicates that early intervention in psychosis may have at least subtle positive effects on the long-term course of illness.
未治疗精神病期（DUP）是精神分裂症结局的少数几个潜在可改变的预测因素之一。以前的荟萃分析已经探讨了长 DUP 作为短期不良结局的预测因素，但 DUP 的长期影响仍不清楚。
分析 DUP 与精神分裂症长期结局之间的关系。
使用七个电子数据库和手动搜索进行系统文献检索。使用加权荟萃分析，计算相关系数，对结果进行合并。
我们确定了 3493 个独特的出版物，其中 33 个样本符合我们预先设定的选择标准。长 DUP 与一般症状结局不良、阳性和阴性症状更严重、缓解的可能性较小以及社会功能和总体结局较差存在统计学上显著相关（相关系数为 0.13-0.18）。长 DUP 与就业、生活质量或住院治疗无关。
长 DUP 与不良结局之间的小但大多一致的相关性表明，精神病早期干预至少可能对疾病的长期病程产生微妙的积极影响。
