对来自巴基斯坦的年龄相关性黄斑变性患者的血脂评估。

Assessment of serum lipids in patients with age related macular degeneration from Pakistan.

作者信息

Ambreen Fareeha, Khan Wajid Ali, Qureshi Nadeem, Qureshi Irfan Zia

出版信息

J Pak Med Assoc. 2014 Jun;64(6):664-9.

PMID:25252486

Abstract

OBJECTIVE

To determine serum lipids in patients with age related macular degeneration from Pakistani population.

METHODS

The study was a cross sectional, randomized and case-control. Selected subjects ages were > or = 50 years and were normotensive, non-diabetic with no family history of any such disease and no complication of posterior ocular chamber other than age related macular degeneration (AMD). Controls were age matched healthy individuals with no symptoms of AMD. Diagnosis of AMD was done through conventional diagnostic techniques by professional ophthalmologists. Serum samples were analyzed for total cholesterol, triglycerides, LDL and HDL using commercially available kits. Data were compared with Student's t-test. Pearson correlation was calculated for relationship between different parameters. P < 0.05 was considered significant.

RESULTS

Compared to controls, AMD patients had significantly greater total cholesterol concentration (p < 0.041), and power HDL/LDL ratio (p < 0.038), while serum triglycerides, HDL and LDL were non-significantly different from control subjects. Total cholesterol in AMD patients was significantly correlated with TG, LDL and HDL (p < 0.0001).

CONCLUSION

The study indicates that high cholesterol might be a predictor of AMD and can be a diagnostic parameter.

摘要

目的

测定巴基斯坦人群中年龄相关性黄斑变性患者的血脂水平。

方法

本研究为横断面、随机、病例对照研究。入选受试者年龄≥50岁，血压正常，无糖尿病，无此类疾病家族史，除年龄相关性黄斑变性（AMD）外无后房并发症。对照组为年龄匹配的无AMD症状的健康个体。AMD的诊断由专业眼科医生通过传统诊断技术进行。使用市售试剂盒分析血清样本中的总胆固醇、甘油三酯、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。数据采用学生t检验进行比较。计算不同参数之间关系的Pearson相关性。P<0.05被认为具有统计学意义。