Roca Patricia, Presentación-Herrero M Jesús, Miranda-Casas Ana, Mulas Fernando, Ortiz-Sánchez Pedro
Instituto Valenciano de Neurologia Pediatrica (INVANEP), 46010 Valencia, Espana.
Rev Neurol. 2014 Feb 24;58 Suppl 1:S51-6.
Deficit in the executive functions has been widely studied in attention deficit hyperactivity disorder (ADHD). The interest in its neurophysiological correlates has led to an improvement in the identification of the symptoms, the characteristics and the treatment of the disorder.
The objective of this study was to analyse the correlation between latency and amplitude of the P300 component and an ecological measure of working memory in a sample of adolescents.
The sample consisted of 24 boys and 7 girls aged between 12 and 18 years. P300 cognitive evoked potentials in auditory mode at Cz were registered and analysed. Furthermore, the parents filled in an executive behaviour home rating scale (BRIEF), which the working memory index was extracted from.
Significant correlations were found between the P300 amplitude and the working memory index of the BRIEF-P.
Results underline the usefulness of the P300 component for the study of its executive correlates, as well as the need to conduct further studies involving larger samples and greater complexity.
执行功能缺陷在注意力缺陷多动障碍（ADHD）中已得到广泛研究。对其神经生理学相关性的关注已使该障碍的症状识别、特征及治疗有所改善。
本研究的目的是分析青少年样本中P300成分的潜伏期和波幅与工作记忆的生态学测量之间的相关性。
样本包括24名男孩和7名女孩，年龄在12至18岁之间。记录并分析了Cz点听觉模式下的P300认知诱发电位。此外，父母填写了一份执行行为家庭评定量表（BRIEF），并从中提取工作记忆指数。
发现P300波幅与BRIEF-P的工作记忆指数之间存在显著相关性。
结果强调了P300成分在研究其执行相关性方面的有用性，以及开展涉及更大样本和更高复杂性的进一步研究的必要性。
