Ungprasert Patompong, Srivali Narat, Wijarnpreecha Karn, Charoenpong Prangthip, Knight Eric L
Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA. Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
Rheumatology (Oxford). 2015 Apr;54(4):736-42. doi: 10.1093/rheumatology/keu408. Epub 2014 Sep 24.
The aim of this study was to integrate and examine the association between NSAID use and venous thromboembolism (VTE).
We conducted a systematic review and meta-analysis of studies that reported odds ratios, relative risks, hazard ratios or standardized incidence ratios for VTE among NSAID users compared with non-users. Pooled risk ratios and 95% CIs were calculated using a random effects generic inverse variance model.
Six studies with 21 401 VTE events were identified and included in the data analysis. The pooled risk ratio of VTE in NSAID users was 1.80 (95% CI 1.28, 2.52).
Our study demonstrated a statistically significant increased risk of VTE among NSAID users. This finding has important public health implications given the prevalence of NSAID use in the general population.
本研究的目的是综合并检验非甾体抗炎药（NSAID）使用与静脉血栓栓塞症（VTE）之间的关联。
我们对报告了NSAID使用者与非使用者中VTE的比值比、相对风险、风险比或标准化发病率比的研究进行了系统评价和荟萃分析。使用随机效应通用逆方差模型计算合并风险比和95%置信区间。
确定了六项研究，其中有21401例VTE事件，并纳入数据分析。NSAID使用者中VTE的合并风险比为1.80（95%置信区间1.28，2.52）。
我们的研究表明NSAID使用者中VTE风险在统计学上显著增加。鉴于NSAID在普通人群中的使用 prevalence，这一发现具有重要的公共卫生意义。 （注：“prevalence”此处原文有误，可能是“prevalence”，意为“流行率、患病率” ）
