Ikdahl Eirik, Kerola Anne, Sollerud Eli, Semb Anne Grete
REMEDY Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital Oslo, Norway.
Department of Rheumatology, Päijät-Häme Joint Authority for Health and Wellbeing Lahti, Finland.
Eur Cardiol. 2024 Dec 23;19:e27. doi: 10.15420/ecr.2024.24. eCollection 2024.
This review examines the cardiovascular risks associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), both traditional NSAIDs and cyclooxygenase-2 selective inhibitors (COXIBs). It describes the history of traditional NSAIDs and the development of COXIBs to explain why their cardiovascular side effects were unnoticed for many decades. Further, the review presents the mechanism of action of NSAIDs, to elucidate the possible underlying basis for why they are associated with an increased risk of cardiovascular disease. Finally, data on the cardiovascular risk with NSAID use in patients with rheumatoid arthritis are presented, and we propose possible explanations for why the risk of cardiovascular side effects in these patients seems to be less pronounced than in the general population.
本综述探讨了使用非甾体抗炎药（NSAIDs），包括传统NSAIDs和环氧化酶-2选择性抑制剂（COXIBs）所带来的心血管风险。它描述了传统NSAIDs的历史以及COXIBs的发展历程，以解释为何它们的心血管副作用在数十年间未被察觉。此外，该综述介绍了NSAIDs的作用机制，以阐明它们为何与心血管疾病风险增加相关的潜在可能原因。最后，展示了类风湿关节炎患者使用NSAIDs的心血管风险数据，并对为何这些患者心血管副作用风险似乎不如普通人群明显提出了可能的解释。
