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皮肤癌:紫外线辐射在致癌过程中的作用

Skin cancer: role of ultraviolet radiation in carcinogenesis.

作者信息

Mancebo Silvia E, Wang Steven Q

出版信息

Rev Environ Health. 2014;29(3):265-73. doi: 10.1515/reveh-2014-0041.

Abstract

UV radiation is a carcinogen known to play a role in the development of non-melanoma and melanoma skin cancers. Acute and chronic exposure to UV radiation causes clinical and biological effects that promote the unregulated proliferation of skin cells. In recent decades, changes in climate and increased air pollution have led to environmental changes that increase UV light transmission. In this chapter, we discuss sources of UV radiation that are relevant to human health, as well as the acute and chronic effects that result from UV radiation exposure.

摘要

紫外线辐射是一种致癌物,已知其在非黑色素瘤和黑色素瘤皮肤癌的发展过程中起作用。急性和慢性暴露于紫外线辐射会导致临床和生物学效应,从而促进皮肤细胞的无节制增殖。近几十年来,气候变化和空气污染加剧导致了环境变化,增加了紫外线的传播。在本章中,我们将讨论与人类健康相关的紫外线辐射源以及紫外线辐射暴露所产生的急性和慢性影响。

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