Marchese-Ragona Rosario, Manfredini Daniele, Mion Marta, Vianello Andrea, Staffieri Alberto, Guarda-Nardini Luca
Cranio. 2014 Oct;32(4):254-9. doi: 10.1179/2151090314Y.0000000003. Epub 2014 May 5.
To assess the effectiveness of mandibular advancement devices (MADs) for the treatment of obstructive sleep apnea syndrome (OSAS) over a long-term follow-up in patients non-compliant with continuous positive airway pressure (CPAP) and to identify potential predictive factors of response to MADs.
Fifteen OSAS patients were enrolled. Apnea-hypopnea index (AHI) and daytime sleepiness were assessed at baseline and at the end of follow-up. Potential baseline predictors of treatment effectiveness were assessed.
AHI and Epworth Sleepiness Scale (ESS) scores improved significantly with MADs. Sixty per cent of patients were 'responders', of whom 33% were 'full responders'. Sixty-seven per cent of patients showed total compliance. No correlations between the potential predictors and the response to MAD therapy were found.
Effectiveness of MAD therapy was shown over a long-term follow-up in OSAS patients with low compliance to CPAP. Efforts to identify predictive success factors fell short.
评估下颌前移装置（MADs）在长期随访中对不依从持续气道正压通气（CPAP）治疗的阻塞性睡眠呼吸暂停综合征（OSAS）患者的治疗效果，并确定对MADs反应的潜在预测因素。
纳入15例OSAS患者。在基线和随访结束时评估呼吸暂停低通气指数（AHI）和日间嗜睡情况。评估治疗效果的潜在基线预测因素。
使用MADs后，AHI和爱泼沃斯嗜睡量表（ESS）评分显著改善。60%的患者为“反应者”，其中33%为“完全反应者”。67%的患者完全依从。未发现潜在预测因素与MAD治疗反应之间存在相关性。
在对CPAP依从性低的OSAS患者的长期随访中显示了MAD治疗的有效性。识别预测成功因素的努力未取得成效。
