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经尿道非肌层浸润性膀胱癌切除术期间因腹膜穿孔导致的肿瘤种植

Tumour seeding as a result of intraperitoneal perforation during transurethral resection of non-muscle invasive bladder cancer.

作者信息

Cusano Antonio, Murphy Greg, Haddock Peter, Wagner Joseph

机构信息

Department of Urology, Hartford Hospital, Hartford, Connecticut, USA.

出版信息

BMJ Case Rep. 2014 Sep 24;2014:bcr2014206631. doi: 10.1136/bcr-2014-206631.

Abstract

The goals of transurethral resection of bladder tumour (TURBT) for urothelial carcinoma are pathological staging and the removal of all visible tumour tissue. Typically, a deep and extensive resection beyond the basement membrane, including some muscularis propria, is performed. However, this also carries a risk of perforating the bladder wall, creating the ideal circumstances to facilitate peritoneal or abdominal metastases. Small, asymptomatic bladder perforations occur frequently and are associated with gender: female, decreasing body mass index, higher tumour stage, deeper infiltration and higher resection weight. Since many of these perforations are extraperitoneal, heal spontaneously and do not elicit any significant perioperative symptoms, they remain undiagnosed. Even in cases of intraperitoneal perforation, peritoneal tumour recurrence has been rarely reported. We report on the unusual case of a 61-year-old woman who underwent TURBT for non-muscle invasive urothelial carcinoma that was complicated by intraperitoneal bladder perforation requiring open repair.

摘要

经尿道膀胱肿瘤切除术(TURBT)治疗尿路上皮癌的目的是进行病理分期以及切除所有可见的肿瘤组织。通常情况下,要进行超出基底膜的深度广泛切除,包括一些固有肌层。然而,这也存在膀胱壁穿孔的风险,从而为促进腹膜或腹腔转移创造了理想条件。小的、无症状的膀胱穿孔经常发生,且与性别有关:女性、体重指数降低、肿瘤分期较高、浸润较深和切除重量较大。由于这些穿孔大多是腹膜外的,可自行愈合且不会引发任何明显的围手术期症状,因此仍未被诊断出来。即使在腹膜内穿孔的情况下,腹膜肿瘤复发也鲜有报道。我们报告了一例不同寻常的病例,一名61岁女性因非肌层浸润性尿路上皮癌接受TURBT,并发腹膜内膀胱穿孔,需要进行开放修复。

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