Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, USA.
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Sci Transl Med. 2014 Sep 24;6(255):255fs37. doi: 10.1126/scitranslmed.3010168.
Heterotopic ossification--a complication of severe burns, head or blast injuries, and orthopaedic trauma--can result from altered adenosine metabolism in mesenchymal stem cells in response to elevated extracellular ATP (Peterson et al., this issue).
异位骨化——一种严重烧伤、头部或爆炸伤以及骨科外伤的并发症——可能是由于细胞外 ATP 升高导致间充质干细胞中腺苷代谢改变所致(Peterson 等人,本期文章)。