Benito-León Julián, Louis Elan D, Villarejo-Galende Alberto, Romero Juan P, Bermejo-Pareja Félix
From the Department of Neurology (J.B.-L., A.V.-G., J.P.R., F.B.-P.), University Hospital 12 de Octubre, Madrid; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) (J.B.-L., F.B.-P.), Spain; Department of Medicine (J.B.-L., A.V.-G., J.P.R., F.B.-P.), Complutense University, Madrid, Spain; G.H. Sergievsky Center (E.D.L.), Department of Neurology (E.D.L.), and Taub Institute for Research on Alzheimer's Disease and the Aging Brain (E.D.L.), College of Physicians and Surgeons, Columbia University; Department of Epidemiology (E.D.L.), Mailman School of Public Health, Columbia University, New York; and Faculty of Biosanitary Sciences (J.P.R.), Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain.
Neurology. 2014 Oct 21;83(17):1530-7. doi: 10.1212/WNL.0000000000000915. Epub 2014 Sep 24.
To determine in a population-based study whether long sleep duration was associated with increased risk of dementia mortality.
In this prospective, population-based study of 3,857 people without dementia aged 65 years and older (NEDICES [Neurological Disorders in Central Spain]), participants reported their daily sleep duration. The average daily total sleep duration was grouped into 3 categories: ≤5 hours (short sleepers), 6-8 hours (reference category), and ≥9 hours (long sleepers). Community-dwelling elders were followed for a median of 12.5 years, after which the death certificates of those who died were examined.
A total of 1,822 (47.2%) of 3,857 participants died, including 201 (11.0%) deaths among short sleepers, 832 (45.7%) among long sleepers, and 789 (43.3%) among those participants in the reference category. Of 1,822 deceased participants, 92 (5.1%) had a dementia condition reported on the death certificate (49 [53.3%] were long sleepers, 36 [39.1%] reported sleeping between 6 and 8 hours, and 7 [7.6%] were short sleepers). In an unadjusted Cox model, risk of dementia-specific mortality was increased in long sleepers (hazard ratio for dementia mortality in long sleepers = 1.58, p = 0.04) when compared with the reference group. In a Cox model that adjusted for numerous demographic factors and comorbidities, the hazard ratio for dementia mortality in long sleepers was 1.63 (p = 0.03).
Self-reported long sleep duration was associated with 58% increased risk of dementia-specific mortality in this cohort of elders without dementia. Future studies are required to confirm these findings.
在一项基于人群的研究中，确定长时间睡眠是否与痴呆症死亡率增加相关。
在这项针对3857名65岁及以上无痴呆症患者的前瞻性人群研究（西班牙中部神经系统疾病[NEDICES]）中，参与者报告了他们的每日睡眠时间。平均每日总睡眠时间分为3类：≤5小时（短睡眠者）、6 - 8小时（参照组）和≥9小时（长睡眠者）。对居住在社区的老年人进行了为期12.5年的中位数随访，之后检查了死亡者的死亡证明。
3857名参与者中共有1822人（47.2%）死亡，其中短睡眠者中有201人（11.0%）死亡，长睡眠者中有832人（45.7%）死亡，参照组中有789人（43.3%）死亡。在1822名死亡参与者中，92人（5.1%）的死亡证明上报告患有痴呆症（49人[53.3%]为长睡眠者，36人[39.1%]报告睡眠时间在6至8小时之间，7人[7.6%]为短睡眠者）。在未调整的Cox模型中，与参照组相比，长睡眠者患痴呆症特异性死亡率的风险增加（长睡眠者痴呆症死亡率的风险比 = 1.58，p = 0.04）。在调整了众多人口统计学因素和合并症的Cox模型中，长睡眠者痴呆症死亡率的风险比为1.63（p = 0.03）。
在这个无痴呆症的老年人群队列中，自我报告的长时间睡眠与痴呆症特异性死亡率风险增加58%相关。需要进一步的研究来证实这些发现。
