Chaudhari Swapnil Y, Ruknuddin Galib, Biswajyoti J Patgiri, Kumar Prajapati Pradeep
Department of Rasa Shastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Toxicol Int. 2014 May;21(2):156-9. doi: 10.4103/0971-6580.139796.
Tamra Bhasma (TB) and its forms like Somnathi Tamra Bhasma (STB), etc., are in vogue since centuries in Ayurveda. The present study is carried out to evaluate the effect of TB and STB in different dose levels on ponderal and biochemical parameters in wistar strain albino rats to provide scientific basis for its safety profile.
TB and STB were prepared as per the classical guidelines and administered to wistar strain albino rats for 45 consecutive days. Blood was collected and rats were sacrificed on the 46(th) day. Ponderal and biochemical parameters were studied.
Results showed significant decrease in serum cholesterol, High Density Lipoprotein (HDL) cholesterol, triglycerides, total protein, and serum alkaline phosphatase levels. Comparatively, all the differences in between the groups are insignificant and no pathological changes at ponderal and biochemical levels were observed.
Based on these observations, it can be said that these formulations can be safely used in cases of hyperlipidemia.
自几个世纪以来，塔姆拉·巴斯马（TB）及其变体，如索姆纳蒂·塔姆拉·巴斯马（STB）等，在阿育吠陀医学中颇为流行。本研究旨在评估不同剂量水平的TB和STB对Wistar品系白化大鼠体重及生化指标的影响，为其安全性提供科学依据。
按照经典指南制备TB和STB，并连续45天给予Wistar品系白化大鼠。在第46天采集血液并处死大鼠，对体重及生化指标进行研究。
结果显示血清胆固醇、高密度脂蛋白（HDL）胆固醇、甘油三酯、总蛋白和血清碱性磷酸酶水平显著降低。相比之下，各组之间的所有差异均不显著，且在体重和生化水平上未观察到病理变化。
基于这些观察结果，可以说这些制剂可安全用于高脂血症病例。
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