塔姆拉煅灰的毒理学及自由基清除特性
Toxicology and free radicals scavenging property of Tamra bhasma.
作者信息
Pattanaik N, Singh Ajita V, Pandey R S, Singh B S, Kumar Mohan, Dixit S K, Tripathi Yamini B
机构信息
Department of Pathology and Rasa Shastra, Institute of Medical Science, Banaras Hindu University, 221005 Varanasi.
出版信息
Indian J Clin Biochem. 2003 Jul;18(2):181-9. doi: 10.1007/BF02867385.
Free radicals are implicated in various chronic diseases. There has always been a search for new antioxidants. In this paper we have investigated Tamra bhasma, a metallic ayurvedic preparation. It is a time-tested medicine in Ayurveda and is in clinical use for various ailments specifically the free radical mediated diseases. Our results show that Tamra bhasma inhibits lipid peroxidation (LPO), prevents the rate of aerial oxidation of reduced glutathione (GSH) content and induces the activity of superoxide dismutase (SOD) in rat liver homogenate in the bi-phasic manner. The drug was orally given for 7, 15 and 30 days in different doses. Best protective response was found at the dose of 0.5mg/100g body weight in albino rats, although it showed some histopathological changes at the dose of 20mg/100g body weight. The results suggest that this Ayurvedic preparation is not merely a source of copper metal, but it is a strong anti-oxidant with no detectable adverse effect in lower doses of therapeutic range.
自由基与多种慢性疾病有关。人们一直在寻找新的抗氧化剂。在本文中，我们研究了一种金属阿育吠陀制剂——铜灰。它是阿育吠陀中经过时间考验的药物，临床上用于治疗各种疾病，特别是自由基介导的疾病。我们的结果表明，铜灰以双相方式抑制大鼠肝匀浆中的脂质过氧化（LPO），阻止还原型谷胱甘肽（GSH）含量的空气氧化速率，并诱导超氧化物歧化酶（SOD）的活性。该药物以不同剂量口服给药7天、15天和30天。在白化病大鼠中，0.5mg/1００g体重的剂量显示出最佳的保护反应，尽管在20mg/1００g体重的剂量下出现了一些组织病理学变化。结果表明，这种阿育吠陀制剂不仅是铜金属的来源，而且是一种强大的抗氧化剂，在较低治疗剂量范围内没有可检测到的不良反应。
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