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下颌骨骨内炎性肌纤维母细胞瘤:1例罕见病理病例报告

Intraosseous inflammatory myofibroblastic tumor in the mandible: a rare pathologic case report.

作者信息

Stringer Dale E, Allen Chad N, Nguyen Katina, Tandon Rahul

机构信息

Loma Linda University, 11092 Anderson Street, 3rd Floor, Room 3307, Loma Linda, CA 92350, USA.

Division of Oral and Maxillofacial Surgery, Parkland Memorial Hospital, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9159, USA.

出版信息

Case Rep Surg. 2014;2014:565478. doi: 10.1155/2014/565478. Epub 2014 Sep 1.

DOI:10.1155/2014/565478
PMID:25254136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4165562/
Abstract

Inflammatory myofibroblastic tumor (IMT) is an extremely rare lesion found in the maxillofacial region. Its frequency diminishes further when found in the bone. Although classification has varied throughout its history, the histologic features are often diagnostic, particularly with its strong association with anaplastic lymphoma kinase-1 (ALK-1) staining. The current mode of treatment for such a lesion is surgical removal with careful followup. In this rare case report, we describe the diagnosis and treatment in a 16-year-old male. Although this rare pathology can present as-and at times mimic-more serious pathologies, it is important for the attending surgeon to initially manage the pathology conservatively.

摘要

炎性肌纤维母细胞瘤(IMT)是一种在颌面部发现的极其罕见的病变。当在骨骼中发现时,其发生率会进一步降低。尽管在其历史上分类有所不同,但其组织学特征通常具有诊断意义,特别是与间变性淋巴瘤激酶-1(ALK-1)染色有很强的相关性。目前针对这种病变的治疗方式是手术切除并进行仔细随访。在这份罕见病例报告中,我们描述了一名16岁男性的诊断和治疗情况。尽管这种罕见的病理情况可能表现为——有时还会模仿——更严重的病理情况,但主治外科医生最初采取保守治疗这种病理情况很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/158567df3d13/CRIS2014-565478.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/d35ba6e688f8/CRIS2014-565478.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/fdcca7149b6f/CRIS2014-565478.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/23c2e1aa0646/CRIS2014-565478.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/158567df3d13/CRIS2014-565478.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/d35ba6e688f8/CRIS2014-565478.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/fdcca7149b6f/CRIS2014-565478.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/23c2e1aa0646/CRIS2014-565478.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b84/4165562/158567df3d13/CRIS2014-565478.004.jpg

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Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report.下颌骨骨内炎性肌纤维母细胞瘤伴新型ATIC-ALK融合突变:病例报告
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Recurrent inflammatory pseudotumor of the jaw with perineural intracranial invasion demonstrating sustained response to Rituximab.复发性颌骨炎性假瘤伴颅神经周围侵犯,对利妥昔单抗有持续反应。
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