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通过NaF18-PET/CT骨扫描研究测得的正常SUV值。

Normal SUV values measured from NaF18- PET/CT bone scan studies.

作者信息

Win Aung Zaw, Aparici Carina Mari

机构信息

Department of Radiology, San Francisco VA Medical Center, San Francisco, California, United States of America.

Department of Radiology, University of California San Francisco (UCSF), San Francisco, California, United States of America.

出版信息

PLoS One. 2014 Sep 25;9(9):e108429. doi: 10.1371/journal.pone.0108429. eCollection 2014.

DOI:10.1371/journal.pone.0108429
PMID:25254490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4177910/
Abstract

OBJECTIVES

Cancer and metabolic bone diseases can alter the SUV. SUV values have never been measured from healthy skeletons in NaF18-PET/CT bone scans. The primary aim of this study was to measure the SUV values from normal skeletons in NaF18-PET/CT bone scans.

METHODS

A retrospective study was carried out involving NaF18- PET/CT bone scans that were done at our institution between January 2010 to May 2012. Our excluding criteria was patients with abnormal real function and patients with past history of cancer and metabolic bone diseases including but not limited to osteoporosis, osteopenia and Paget's disease. Eleven studies met all the criteria.

RESULTS

The average normal SUVmax values from 11 patients were: cervical vertebrae 6.84 (range 4.38-8.64), thoracic vertebrae 7.36 (range 6.99-7.66), lumbar vertebrae 7.27 (range 7.04-7.72), femoral head 2.22 (range 1.1-4.3), humeral head 1.82 (range 1.2-2.9), mid sternum 5.51 (range 2.6-8.1), parietal bone 1.71 (range 1.3-2.4).

CONCLUSION

According to our study, various skeletal sites have different normal SUV values. SUV values can be different between the normal bones and bones with tumor or metabolic bone disease. SUV can be used to quantify NaF-18 PET/CT studies. If the SUV values of the normal skeleton are known, they can be used in the characterization of bone lesions and in the assessment of treatment response to bone diseases.

摘要

目的

癌症和代谢性骨病可改变标准化摄取值（SUV）。在18F-NaF PET/CT骨扫描中，从未对健康骨骼的SUV值进行过测量。本研究的主要目的是测量18F-NaF PET/CT骨扫描中正常骨骼的SUV值。

方法

进行了一项回顾性研究，纳入了2010年1月至2012年5月在本机构进行的18F-NaF PET/CT骨扫描。我们的排除标准是肾功能异常的患者以及有癌症和代谢性骨病病史的患者，包括但不限于骨质疏松症、骨质减少症和佩吉特病。11项研究符合所有标准。

结果

11例患者的平均正常SUV最大值为：颈椎6.84（范围4.38 - 8.64），胸椎7.36（范围6.99 - 7.66），腰椎7.27（范围7.04 - 7.72），股骨头2.22（范围1.1 - 4.3），肱骨头1.82（范围1.2 - 2.9），胸骨中段5.51（范围2.6 - 8.1），顶骨1.71（范围1.3 - 2.4）。

结论

根据我们的研究，不同骨骼部位有不同的正常SUV值。正常骨骼与有肿瘤或代谢性骨病的骨骼之间的SUV值可能不同。SUV可用于量化18F-NaF PET/CT研究。如果已知正常骨骼的SUV值，它们可用于骨病变的特征描述以及骨病治疗反应的评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe81/4177910/fa7ca648995a/pone.0108429.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe81/4177910/c20778c6a699/pone.0108429.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe81/4177910/fa7ca648995a/pone.0108429.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe81/4177910/c20778c6a699/pone.0108429.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe81/4177910/fa7ca648995a/pone.0108429.g002.jpg

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