Nawata Shintaro, Kaneta Tomohiro, Ogawa Matsuyoshi, Ishiwata Yoshinobu, Kobayashi Naomi, Shishikura-Hino Ayako, Yoshida Keisuke, Inaba Yutaka, Saito Tomoyuki, Inoue Tomio
Tomohiro Kaneta Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama,, Kanagawa 236-0004, Japan, E-Mail:
Nuklearmedizin. 2017 Jun 12;56(3):91-96. doi: 10.3413/Nukmed-0867-16-12. Epub 2017 May 10.
The aim of this study was to evaluate the normal distribution of sodium fluoride-18 (NaF-18) and to clarify the differences in uptake according to location and the type of the bone using positron emission tomography (PET) / computed tomography (CT).
We retrospectively reviewed NaF-18 PET/CT images from 30 patients with hip joint disorders. PET/CT scans were performed 40 min after injection of approximately 185 MBq of NaF-18. To evaluate the relationship between the distribution of NaF-18 uptake and bone density, we compared the maximum standardised uptake values (SUV) on PET and the Hounsfield Units (HUs) on CT of the lumbar vertebra, ilium, and proximal and distal femurs. Regions of interests were defined both outside and inside the cortical bone to measure whole bone and cancellous bone only, respectively.
The distribution of NaF-18 differed according to the skeletal site. The lumbar vertebra showed the highest SUV for both whole bone and cancellous bone, followed by the ilium, proximal femur, and distal femur. The bones differed significantly in SUV. The distal femur showed the highest HU, followed by the proximal femur, ilium, and vertebra. Profile curve analyses demonstrated that the cancellous bones showed higher SUV and lower HU than the cortical bones.
Our results demonstrate the difference in NaF-18 uptake between cancellous and cortical bones, which may explain differences in uptake by location. NaF-18 uptake does not appear to be strongly correlated with bone density, but rather with bone turnover and blood flow.
本研究旨在评估18氟氟化钠（NaF-18）的正常分布，并使用正电子发射断层扫描（PET）/计算机断层扫描（CT）阐明根据骨骼位置和类型的摄取差异。
我们回顾性分析了30例髋关节疾病患者的NaF-18 PET/CT图像。在注射约185 MBq的NaF-18后40分钟进行PET/CT扫描。为了评估NaF-18摄取分布与骨密度之间的关系，我们比较了腰椎、髂骨、股骨近端和远端的PET上的最大标准化摄取值（SUV）和CT上的亨氏单位（HU）。分别在皮质骨内外定义感兴趣区域，以仅测量全骨和松质骨。
NaF-18的分布因骨骼部位而异。腰椎在全骨和松质骨中均显示出最高的SUV，其次是髂骨、股骨近端和远端。不同骨骼的SUV差异显著。股骨远端显示出最高的HU，其次是股骨近端、髂骨和椎骨。轮廓曲线分析表明，松质骨的SUV高于皮质骨，HU低于皮质骨。
我们的结果表明松质骨和皮质骨之间NaF-18摄取存在差异，这可能解释了不同位置摄取的差异。NaF-18摄取似乎与骨密度没有强烈相关性，而是与骨转换和血流有关。
