Hegeman J M, de Waal M W M, Comijs H C, Kok R M, van der Mast R C
Department of Psychiatry, St. Antoniusziekenhuis, Utrecht, The Netherlands; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
J Affect Disord. 2015 Jan 1;170:196-202. doi: 10.1016/j.jad.2014.08.032. Epub 2014 Aug 30.
Depression later in life may have a more somatic presentation compared with depression earlier in life due to chronic somatic disease and increasing age. This study examines the influence of the presence of chronic somatic diseases and increasing age on symptom dimensions of late-life depression.
Baseline data of 429 depressed and non-depressed older persons (aged 60-93 years) in the Netherlands Study of Depression in Old Age were used, including symptom dimension scores as assessed with the mood, somatic and motivation subscales of the Inventory of Depressive Symptomatology-Self Report (IDS-SR). Linear regression was performed to investigate the effect of chronic somatic diseases and age on the IDS-SR subscale scores.
In depressed older persons a higher somatic disease burden was associated with higher scores on the mood subscale (B = 2.02, p = 0.001), whereas higher age was associated with lower scores on the mood (B = -2.30, p < 0.001) and motivation (B = -1.01, p = 0.006) subscales. In depressed compared with non-depressed persons, a higher somatic disease burden showed no different association with higher scores on the somatic subscale (F(1,12) = 9.2; p = 0.003; partial η(2)=0.022).
Because the IDS-SR subscales are specific for old age, it was not feasible to include persons aged < 60 years to investigate differences between earlier and later life.
It seems that neither higher somatic disease burden nor higher age contributes to more severe somatic symptoms in late-life depression. In older old persons aged ≥ 70 years, late-life depression may not be adequately recognized because they may show less mood and motivational symptoms compared with younger old persons.
由于慢性躯体疾病和年龄增长,老年期抑郁症与早年抑郁症相比可能有更多的躯体表现。本研究探讨慢性躯体疾病的存在和年龄增长对老年期抑郁症症状维度的影响。
使用荷兰老年抑郁症研究中429名抑郁和非抑郁老年人(年龄60 - 93岁)的基线数据,包括用抑郁症状自评量表(IDS - SR)的情绪、躯体和动机分量表评估的症状维度得分。进行线性回归以研究慢性躯体疾病和年龄对IDS - SR分量表得分的影响。
在抑郁的老年人中,较高的躯体疾病负担与情绪分量表得分较高相关(B = 2.02,p = 0.001),而较高年龄与情绪(B = -2.30,p < 0.001)和动机(B = -1.01,p = 0.006)分量表得分较低相关。与非抑郁者相比,抑郁者中较高的躯体疾病负担与躯体分量表得分较高的关联无差异(F(1,12) = 9.2;p = 0.003;偏η(2)=0.022)。
由于IDS - SR分量表是针对老年人的,纳入年龄<60岁的人来研究早年和晚年的差异不可行。
似乎较高的躯体疾病负担和较高年龄均不会导致老年期抑郁症的躯体症状更严重。在70岁及以上的高龄老年人中,老年期抑郁症可能未得到充分认识,因为与年轻老年人相比,他们可能表现出较少的情绪和动机症状。