Wattig B, Warzok R, Röder H, Hufnagl P, Huyoff K
Institut für Pathologische Anatomie, Bereichs Medizin der Ernst-Moritz-Arndt-Universität Greifswald.
Gegenbaurs Morphol Jahrb. 1989;135(1):103-8.
Electrophysiologic studies of posterior tibial nerves by averaging method and morphometric investigations of sural nerves by automatic image analysis were performed in 7 non-diabetic rats 42 d after the administration of 55 mg streptozotocin/kg b.w. and in 10 untreated controls. Morphometry of stained semithin sections was carried out with system A 6471-AMBA/R (Robotron, Dresden, G.D.R.). There was no decrease of motor nerve conduction velocity in streptozotocin injected animals. The investigated morphometric parameters showed no significant alterations in the streptozotocin group. The studies show that in streptozotocin diabetic rats electrophysiological and morphological alterations of the peripheral nerve are caused by hyperglycemia but not by direct neurotoxic effects of streptozotocin.
对7只非糖尿病大鼠在给予55mg链脲佐菌素/千克体重42天后以及10只未处理的对照大鼠进行了采用平均法的胫后神经电生理研究和采用自动图像分析的腓肠神经形态学研究。用A 6471 - AMBA/R系统（民主德国德累斯顿的Robotron公司）对染色的半薄切片进行形态学测量。注射链脲佐菌素的动物中运动神经传导速度没有降低。所研究的形态学参数在链脲佐菌素组中没有显示出显著变化。这些研究表明，在链脲佐菌素诱导的糖尿病大鼠中，周围神经的电生理和形态学改变是由高血糖引起的，而不是由链脲佐菌素的直接神经毒性作用引起的。
