Wattig B, Warzok R, von Zglinicki T
Institut für Pathologische Anatomie des Bereichs Medizin der Ernst-Moritz-Arndt-Universität Greifs-wald.
Gegenbaurs Morphol Jahrb. 1989;135(1):207-9.
Morphometric studies of sural nerves and dorsal root ganglia cells L5 were performed in 8 diabetic rats 35 or 44d after the administration of streptozotocin and in 8 controls. Morphometry of photographed semithin sections was realized after whole body glutaraldehyde perfusion with semiautomatic MOP AM 02 and MOP Videoplan. The peripheral nerve showed no decrease of the total nerve area, number of nerve fibres or of myelinated area. Parameters area of fibres decreased in diabetic animals caused by reduction of myelin sheath thickness. There were no changes of mean neuron volume and maximal cell diameter in the dorsal root ganglia. Whereas in experimental short-term diabetes the peripheral nerves demonstrate morphologic changes correlating to biochemical abnormalities, no such correlations can be observed in the perikarya. It is suggested, that primary SCHWANN cell lesion is responsible for the observed myelin thickness reduction.
对8只在注射链脲佐菌素后35天或44天的糖尿病大鼠以及8只对照大鼠的腓肠神经和L5背根神经节细胞进行了形态测量研究。在用戊二醛全身灌注后，使用半自动MOP AM 02和MOP Videoplan对拍摄的半薄切片进行形态测量。周围神经的总神经面积、神经纤维数量或有髓面积均未减少。糖尿病动物中纤维面积参数因髓鞘厚度减小而降低。背根神经节中的平均神经元体积和最大细胞直径没有变化。虽然在实验性短期糖尿病中，周围神经表现出与生化异常相关的形态学变化，但在核周体中未观察到此类相关性。提示原发性施万细胞病变是观察到的髓鞘厚度降低的原因。
