Diestelhorst M, Krieglstein G K
Fortschr Ophthalmol. 1989;86(2):89-91.
The human atrial natriuretic factor (hANF) is a cardiovascular hormone, which promotes renal sodium secretion in response to increases in extracellular fluid volume and atrial pressure. It regulates sodium and volume homeostasis. Specific receptors for hANF have been identified in the ciliary processes of rats and rabbits, which mediated a long-lasting reduction in intraocular pressure (IOP) after intra-atrial injection. In a series of 10 glaucoma patients with bilateral IOP elevations above 33 mmHg an i.v. bolus injection of hANF was administered and IOP was recorded before and over an 8-h period after injection. The human atrial natriuretic factor lowered IOP significantly. The potential of hANF as an antiglaucoma agent is discussed.
人心房利钠因子（hANF）是一种心血管激素，它可响应细胞外液量和心房压力的增加促进肾脏排钠。它调节钠和容量稳态。在大鼠和兔子的睫状体中已鉴定出hANF的特异性受体，心房内注射后可介导眼压（IOP）的长期降低。在一系列10例双侧眼压升高超过33 mmHg的青光眼患者中，静脉推注hANF，并在注射前和注射后8小时内记录眼压。人心房利钠因子显著降低了眼压。讨论了hANF作为抗青光眼药物的潜力。
