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The intraocular pressure response of human atrial natriuretic factor in glaucoma.

作者信息

Diestelhorst M, Krieglstein G K

机构信息

Univ. Eye Hospital Cologne/FRG.

出版信息

Int Ophthalmol. 1989 Jan;13(1-2):99-101. doi: 10.1007/BF02028647.

DOI:10.1007/BF02028647
PMID:2526103
Abstract

In an open label, single dose study on ten glaucoma patients with bilateral untreated IOP levels exceeding 30 mmHg the effects of 100 micrograms human atrial natriuretic factor (HANF) on IOP, systolic blood pressure, pulse rate and serum electrolytes were investigated. The intravenous application of HANF decreased IOP over more than 8 hrs. The magnitude of IOP reduction in this study was in the range of 4-7 mmHg. There was no significant change in blood pressure, pulse rate or serum electrolytes. The verified, yet still limited efficacy of HANF on IOP in glaucoma warrants further investigations.

摘要

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本文引用的文献

1
Localization and characterization of specific receptors for atrial natriuretic factor in the ciliary processes of the eye.眼睫状体中的心钠素特异性受体的定位与特性研究
Curr Eye Res. 1986 Apr;5(4):283-93. doi: 10.3109/02713688609020054.
2
Pharmacologic effects of atrial natriuretic peptide.心房利钠肽的药理作用。
Endocrinol Metab Clin North Am. 1987 Mar;16(1):163-82.
3
Synthetic atrial natriuretic factor lowers rabbit intraocular pressure.合成心房利钠因子可降低兔眼压。
睫状体上皮细胞上利钠肽受体的差异调节
Biochem J. 1997 May 15;324 ( Pt 1)(Pt 1):49-55. doi: 10.1042/bj3240049.
4
Mapping of a gene for autosomal dominant juvenile-onset open-angle glaucoma to chromosome Iq.常染色体显性青少年型开角型青光眼基因定位于1号染色体长臂。
Am J Hum Genet. 1994 Jan;54(1):62-70.
5
Evidence for a new role of natriuretic peptides: control of intraocular pressure.利钠肽新作用的证据：眼内压的控制。
Br J Ophthalmol. 1994 Jun;78(6):446-8. doi: 10.1136/bjo.78.6.446.
6
The effect of isosorbide-mononitrate eye drops on the human intraocular pressure and aqueous humor dynamics.单硝酸异山梨酯滴眼液对人眼内压及房水动力学的影响。
Int Ophthalmol. 1991 Jul;15(4):259-62. doi: 10.1007/BF00171028.
Eur J Pharmacol. 1986 Nov 4;130(3):349-50. doi: 10.1016/0014-2999(86)90292-x.
4
[Atrial natriuretic factor. Endocrine function of the heart].[心房利钠因子。心脏的内分泌功能]
Dtsch Med Wochenschr. 1986 Nov 28;111(48):1849-55. doi: 10.1055/s-2008-1068725.
5
Atrial natriuretic hormones--thirty years after the discovery of atrial volume receptors.心房利钠激素——心房容量感受器发现30年后
Klin Wochenschr. 1986 Aug 15;64(16):719-31. doi: 10.1007/BF01734338.
6
Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis.心房肽：一种与体液、电解质及血压稳态密切相关的心脏激素。
N Engl J Med. 1986 Mar 27;314(13):828-34. doi: 10.1056/NEJM198603273141306.
7
Atriopeptin-activated guanylate cyclase in the anterior segment. Identification, localization, and effects of atriopeptins on IOP.心房肽激活眼前节中的鸟苷酸环化酶。心房肽对眼压的鉴定、定位及作用。
Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1357-64.