Gao Wei-Jing, Li Wei-Cui, Zeng Cheng-Chu, Tian Hong-Yu, Hu Li-Ming, Little R Daniel
College of Life Science & Bioengineering, Beijing University of Technology , Beijing 100124, China.
J Org Chem. 2014 Oct 17;79(20):9613-8. doi: 10.1021/jo501736w. Epub 2014 Oct 6.
An electrochemically promoted coupling of benzoxazoles and amines has been developed, leading directly to the formation of 2-aminobenzoxazoles. The chemistry utilizes catalytic quantities of a tetraalkylammonium halide redox catalyst and is carried out under constant current conditions in a simple undivided cell. The use of excess chemical oxidant or large amounts of supporting electrolyte is avoided. This greatly simplifies the workup and isolation process and leads to a reduction in waste.
已开发出一种电化学促进的苯并恶唑与胺的偶联反应，可直接生成2-氨基苯并恶唑。该化学方法利用催化量的四烷基卤化铵氧化还原催化剂，并在简单的无隔膜电池中恒流条件下进行。避免了使用过量的化学氧化剂或大量的支持电解质。这极大地简化了后处理和分离过程，并减少了废物产生。
