Magdy Nancy, Ayad Miriam F
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 25;137:685-91. doi: 10.1016/j.saa.2014.08.042. Epub 2014 Sep 10.
Two simple, accurate, precise, sensitive and economic spectrophotometric methods were developed for the simultaneous determination of Simvastatin and Ezetimibe in fixed dose combination products without prior separation. The first method depends on a new chemometrics-assisted ratio spectra derivative method using moving window polynomial least square fitting method (Savitzky-Golay filters). The second method is based on a simple modification for the ratio subtraction method. The suggested methods were validated according to USP guidelines and can be applied for routine quality control testing.
开发了两种简单、准确、精密、灵敏且经济的分光光度法，用于不经预先分离同时测定固定剂量复方制剂中的辛伐他汀和依折麦布。第一种方法基于一种新的化学计量学辅助比率光谱导数法，该方法使用移动窗口多项式最小二乘法拟合（Savitzky-Golay滤波器）。第二种方法基于对比率减法的简单改进。所建议的方法根据美国药典指南进行了验证，可用于常规质量控制检测。
