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幼年局灶性皮质发育不良(FCD)的电临床病理相关性

Electro-clinical-pathological correlations in focal cortical dysplasia (FCD) at young ages.

作者信息

Holthausen Hans, Pieper Tom, Winkler Peter, Bluemcke Ingmar, Kudernatsch Manfred

机构信息

Neuropediatric Clinic and Clinic for Neurorehabilitation, Epilepsy Center for Children and Adolescents, Schoen-Klinik Vogtareuth, Krankenhausstr. 20, D - 83569, Vogtareuth, Germany,

出版信息

Childs Nerv Syst. 2014 Dec;30(12):2015-26. doi: 10.1007/s00381-014-2549-6. Epub 2014 Sep 27.

DOI:10.1007/s00381-014-2549-6
PMID:25255773
Abstract

The prevalence of focal cortical dysplasia (FCD) in pediatric patients with focal epilepsy is not exactly known because authors of publications in which the etiologies of epilepsies are listed, but which are not dealing specifically with epilepsy surgery issues, tend to lump together the many kinds of malformations of cortical development (MCD), of which FCDs, because of their relative frequency, are the most relevant subtypes. Out of 561 patients with MCD (children and adults) operated at centers in Europe who do feed data into the "European Epilepsy Brain Bank," 426 (76 %) had FCD.

摘要

局灶性皮质发育异常(FCD)在患有局灶性癫痫的儿科患者中的患病率尚不完全清楚,因为在列出癫痫病因但未专门涉及癫痫手术问题的出版物中,作者往往将多种皮质发育畸形(MCD)归为一类,其中FCD由于相对常见,是最相关的亚型。在欧洲各中心接受手术的561例MCD患者(儿童和成人)中,有426例(76%)患有FCD,这些患者的数据被录入了“欧洲癫痫脑库”。

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本文引用的文献

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Toward routine genetics-based diagnoses for the epileptic encephalopathies.迈向基于遗传学的癫痫性脑病常规诊断。
Epilepsy Curr. 2014 May;14(3):158-60. doi: 10.5698/1535-7597-14.3.158.
2
Epilepsies associated with focal cortical dysplasias (FCDs).与局灶性皮质发育不良(FCDs)相关的癫痫。
Acta Neuropathol. 2014 Jul;128(1):5-19. doi: 10.1007/s00401-014-1304-0. Epub 2014 Jun 12.
3
Magnetic resonance imaging abnormalities in the resection region correlate with histopathological type, gliosis extent, and postoperative outcome in pediatric cortical dysplasia.
小儿皮质发育不良切除区域的磁共振成像异常与组织病理学类型、胶质增生程度及术后结果相关。
J Neurosurg Pediatr. 2014 Jul;14(1):68-80. doi: 10.3171/2014.3.PEDS13560. Epub 2014 May 9.
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Diagnostic test utilization in evaluation for resective epilepsy surgery in children.诊断检测在儿童可切除性癫痫手术评估中的应用。
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Hypermotor seizures in lateral and mesial parietal epilepsy.偏侧和内侧顶叶癫痫中的过度运动性发作。
Epilepsy Behav. 2013 Sep;28(3):408-12. doi: 10.1016/j.yebeh.2013.05.030. Epub 2013 Jul 18.
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Seizure outcome of infantile spasms with focal cortical dysplasia.伴有局灶性皮质发育异常的婴儿痉挛症的癫痫发作转归
Brain Dev. 2013 Sep;35(8):816-20. doi: 10.1016/j.braindev.2013.06.013. Epub 2013 Jul 16.
8
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Brain Dev. 2013 Sep;35(8):730-41. doi: 10.1016/j.braindev.2013.05.003. Epub 2013 Jun 20.
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