Guo D, Hu J
Centre for Integrative Neuroscience (CIN), Otfried-Mueller-Straße 25, 72076 Tuebingen, Germany.
Centre for Integrative Neuroscience (CIN), Otfried-Mueller-Straße 25, 72076 Tuebingen, Germany.
Neuroscience. 2014 Dec 26;283:95-106. doi: 10.1016/j.neuroscience.2014.09.032. Epub 2014 Sep 22.
The gate control theory proposed that the nociceptive sensory information transmitted to the brain relies on an interplay between the inputs from nociceptive and non-nociceptive primary afferent fibers. Both inputs are normally under strong inhibitory control in the spinal cord. Under healthy conditions, presynaptic inhibition activated by non-nociceptive fibers modulates the afferent input from nociceptive fibers onto spinal cord neurons, while postsynaptic inhibition controls the excitability of dorsal horn neurons, and silences the non-nociceptive information flow to nociceptive-specific (NS) projection neurons. However, under pathological conditions, this spinal inhibition may be altered and lead to chronic pain. This review summarizes our knowledge of presynaptic inhibition in pain control, with particular focus on how its alteration after nerve or tissue injury contributes to neuropathic or inflammatory pain syndromes, respectively.
闸门控制理论提出，传递至大脑的伤害性感觉信息依赖于伤害性和非伤害性初级传入纤维输入之间的相互作用。在脊髓中，这两种输入通常都受到强大的抑制性控制。在健康状态下，由非伤害性纤维激活的突触前抑制调节伤害性纤维向脊髓神经元的传入输入，而突触后抑制控制背角神经元的兴奋性，并使非伤害性信息流对伤害性特异性（NS）投射神经元保持沉默。然而，在病理状态下，这种脊髓抑制可能会改变并导致慢性疼痛。本综述总结了我们对疼痛控制中突触前抑制的认识，尤其关注神经或组织损伤后其改变如何分别导致神经性或炎性疼痛综合征。
