Ma Jia, Fang Binbin, Zeng Fanpeng, Pang Haijie, Zhang Jing, Shi Ying, Wu Xueping, Cheng Long, Ma Cong, Xia Jun, Wang Zhiwei
Department of Biochemistry and Molecular Biology, Bengbu Medical College, 2600 Donghai Avenue, Anhui 233030, China.
Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui 233030, China.
Toxicol Lett. 2014 Nov 18;231(1):82-91. doi: 10.1016/j.toxlet.2014.09.014. Epub 2014 Sep 23.
Accumulating evidence has revealed that a natural compound curcumin exerts its anti-tumor activity in pancreatic cancer. However, the underlying molecular mechanism remains elusive. Recently, miRNAs have been demonstrated to play a crucial role in tumorigenesis, suggesting that targeting miRNAs could be a promising approach for the treatment of human cancers. In this study, we explored whether curcumin regulates miR-7, leading to the inhibition of cell growth, migration and invasion in pancreatic cancer cells. We observed that curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7 and subsequently decreased expression of SET8, one of the miR-7 targets. These findings demonstrated that targeting miR-7 by curcumin could be a novel strategy for the treatment of pancreatic cancer.
越来越多的证据表明，天然化合物姜黄素在胰腺癌中发挥其抗肿瘤活性。然而，其潜在的分子机制仍然难以捉摸。最近，微小RNA（miRNAs）已被证明在肿瘤发生中起关键作用，这表明靶向miRNAs可能是治疗人类癌症的一种有前途的方法。在本研究中，我们探讨了姜黄素是否调节miR-7，从而导致胰腺癌细胞的生长、迁移和侵袭受到抑制。我们观察到姜黄素抑制细胞生长、迁移和侵袭，并诱导细胞凋亡，这与miR-7表达增加以及随后miR-7靶标之一SET8表达降低有关。这些发现表明，姜黄素靶向miR-7可能是治疗胰腺癌的一种新策略。
