Li Meiyan, Tang Dandan, Yang Ting, Qian Die, Xu Runchun
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2022 Feb 9;12:796300. doi: 10.3389/fphar.2021.796300. eCollection 2021.
Pancreatic cancer, a poor prognosis and high morbidity and mortality cancer, is a malignant tumor occurring in pancreatic exocrine glands. Currently, surgery and gemcitabine (Gem) are commonly used to treat pancreatic cancers. However, the high recurrence rate and resistance makes the therapeutic effects still unsatisfied. Apoptosis is comprehensively recognized as one of the major ways of the programmed cell death, refers to the autonomous and orderly death process of cells in order to maintain the stability of the body's environment after receiving a certain signal or stimulation. Currently, it has also been proven to be a promising way for the treatment of pancreatic cancer. Nowadays, some active ingredients from herbal medicine have been reported to be effective for the treatment of pancreatic cancer via inducing cells apoptosis. Therefore, this article reviews the current references regarding anti pancreatic cancer effects of natural products derived from herbal medicines via triggering apoptosis, and summarizes the related potential signal pathways, including death receptors mediated apoptotic pathway, mitochondrial dependent apoptotic pathway, NF-κB mediated apoptotic pathways, MAPK mediated apoptotic pathway, ERS mediated apoptotic pathway, PI3K-Akt mediated apoptotic pathway, and other pathways such as JAK-STAT signal pathway, which can lay a certain foundation for the research and development of new natural products against pancreatic cancer.
胰腺癌是一种发生于胰腺外分泌腺的恶性肿瘤，预后较差，发病率和死亡率都很高。目前，手术和吉西他滨（Gem）是治疗胰腺癌的常用方法。然而，高复发率和耐药性使得治疗效果仍不尽人意。细胞凋亡被广泛认为是程序性细胞死亡的主要方式之一，是指细胞在受到一定信号或刺激后，为维持机体环境稳定而自主有序的死亡过程。目前，它也已被证明是一种有前景的胰腺癌治疗方法。如今，据报道一些来自草药的活性成分可通过诱导细胞凋亡有效治疗胰腺癌。因此，本文综述了目前关于草药来源的天然产物通过触发细胞凋亡发挥抗胰腺癌作用的参考文献，并总结了相关潜在信号通路，包括死亡受体介导的凋亡途径、线粒体依赖性凋亡途径、NF-κB介导的凋亡途径、MAPK介导的凋亡途径、内质网应激（ERS）介导的凋亡途径、PI3K-Akt介导的凋亡途径，以及其他途径如JAK-STAT信号通路，这可为新型抗胰腺癌天然产物的研发奠定一定基础。
