Ojo Oluwafemi Adeleke, Adeyemo Temiloluwa Rhoda, Rotimi Damilare, Batiha Gaber El-Saber, Mostafa-Hedeab Gomaa, Iyobhebhe Matthew Eboseremen, Elebiyo Tobiloba Christiana, Atunwa Bukola, Ojo Adebola Busola, Lima Clara Mariana Goncalves, Conte-Junior Carlos Adam
Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratories, Department of Biochemistry, Landmark University, Omu-Aran, Nigeria.
Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratories, Department of Biochemistry, Bowen University, Iwo, Nigeria.
Front Oncol. 2022 Apr 22;12:881641. doi: 10.3389/fonc.2022.881641. eCollection 2022.
Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well as the world's second largest cause of mortality. Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year. As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat CRC. These chemicals are phenolic compounds that belong to the curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines and a variety of mechanisms, including the suppression of intrinsic and extrinsic apoptotic signaling pathways, the stoppage of the cell cycle, and the activation of autophagy. Curcumin also has anti-angiogenesis properties. Thus, this review is aimed at emphasizing the biological effect and mode of action of curcumin on CRC. Furthermore, the critical role of these substances in CRC chemoprevention was emphasized.
结直肠癌（CRC）是最常见且易复发的疾病之一，也是全球第二大致死原因。尽管存在化疗等现有的预防、诊断和治疗方法，但病例数量仍逐年上升。因此，应研发针对特定检查点的新型有效药物来对抗结直肠癌。天然化合物，如姜黄素，在可用于治疗结直肠癌的药物中显示出显著的抗结直肠癌特性。这些化学物质是属于姜黄素类的酚类化合物。姜黄素通过多种机制对结直肠癌细胞系发挥其抗增殖特性，包括抑制内在和外在凋亡信号通路、阻断细胞周期以及激活自噬。姜黄素还具有抗血管生成特性。因此，本综述旨在强调姜黄素对结直肠癌的生物学效应和作用方式。此外，还强调了这些物质在结直肠癌化学预防中的关键作用。
