University of Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216, CNRS, Paris, France.
University of Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216, CNRS, Paris, France.
Semin Cell Dev Biol. 2015 Jan;37:82-9. doi: 10.1016/j.semcdb.2014.09.012. Epub 2014 Sep 26.
This review surveys the contributions of protein tyrosine phosphatases (PTPs) to maintenance and differentiation of stem and progenitor cells. A diverse family of PTPs acts at multiple steps of signaling cascades and cellular locales. Their activities as signaling modifiers provide another layer of integration of signaling pathways, which functionally link to the cellular activity and ultimately converge into the regulation of stem and progenitor cell fates. The development of agents targeting PTPs is a growing endeavor that will benefit stem cell biology and offer promising therapeutic strategies.
这篇综述考察了蛋白酪氨酸磷酸酶（PTPs）在维持和分化干细胞和祖细胞方面的贡献。一个多样化的 PTP 家族在信号级联和细胞位置的多个步骤中发挥作用。它们作为信号修饰剂的活性提供了信号通路整合的另一层，这在功能上与细胞活性相关，并最终汇聚到干细胞和祖细胞命运的调节上。靶向 PTP 的药物的开发是一项不断发展的努力，将有益于干细胞生物学，并提供有前途的治疗策略。
