Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India.
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India.
Carbohydr Polym. 2014 Nov 26;113:532-8. doi: 10.1016/j.carbpol.2014.07.041. Epub 2014 Jul 29.
Microwave-assisted synthesis of graft copolymer of carboxymethyl tamarind seed polysaccharide and polyacrylonitrile was carried out. The effect of formulation and process variables on grafting efficiency of carboxymethyl tamarind kernel polysaccharide-g-poly(acrylonitrile) was studied using response surface methodology. The results revealed that the significant factors affecting grafting efficiency were concentrations of ammonium persulphate, acrylonitrile and interaction effects of ammonium persulphate and acrylonitrile concentrations. The optimal calculated parameters were found to be microwave exposure time-99.48 s, microwave exposure power-160 W, concentration of acrylonitrile-0.10% (w/v), concentration of ammonium persulphate--40 mmol/l, which provided graft copolymer with grafting efficiency of 96%. The formation of graft copolymer was confirmed by FT-IR studies and validated by scanning electron micrographs. Thermogravimetric analysis indicated higher thermal stability of graft copolymer and X-ray diffraction study revealed increase in crystallinity on graft polymerization. Further, the graft copolymer showed pH dependant swelling.
采用微波辅助法合成了羧甲基罗望子胶多糖接枝聚丙烯腈共聚物。利用响应面法研究了配方和工艺变量对接枝效率的影响。结果表明，影响接枝效率的显著因素是过硫酸铵、丙烯腈的浓度和过硫酸铵与丙烯腈浓度的交互作用。最佳计算参数为微波辐射时间-99.48 s、微波辐射功率-160 W、丙烯腈浓度-0.10%（w/v）、过硫酸铵浓度-40 mmol/L，在此条件下接枝共聚物的接枝效率为 96%。FT-IR 研究证实了接枝共聚物的形成，并通过扫描电子显微镜照片进行了验证。热重分析表明接枝共聚物具有更高的热稳定性，X 射线衍射研究表明接枝聚合后结晶度增加。此外，接枝共聚物表现出 pH 值依赖的溶胀性。
