Ahuja Munish
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, 125001, India.
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, 125001, India.
Int J Biol Macromol. 2015 Jan;72:931-8. doi: 10.1016/j.ijbiomac.2014.09.040. Epub 2014 Oct 7.
The purpose of present study was to prepare composite hydrogels of carboxymethyl tamarind kernel polysaccharide and polyvinyl alcohol employing freeze thaw-treatment and evaluate them for release behavior. The effect of concentrations of carboxymethyl tamarind kernel polysaccharide, polyvinyl alcohol, and freeze-thaw cycles on the % release of metronidazole was studied employing central composite experimental design. The result of the study revealed that the concentration of carboxymethyl tamarind kernel polysaccharide and interaction effect of concentrations of carboxymethyl tamarind kernel polysaccharide and polyvinyl alcohol influenced the release of metronidazole significantly. The optimal calculated parameters were concentration of carboxymethyl tamarind kernel polysaccharide-6.0% (w/v), concentration of polyvinyl alcohol-8.53% (w/v) and freeze-thaw cycles-4, which provided cryogels with a release of 75.77% over a period of 6h. The formation of cryogels was confirmed by Fourier-transformed infrared spectroscopy and X-ray diffraction studies. Thermal studies revealed higher thermal stability of cryogel.
本研究的目的是采用冻融处理制备羧甲基罗望子多糖与聚乙烯醇的复合水凝胶，并评估其释放行为。采用中心复合实验设计研究了羧甲基罗望子多糖、聚乙烯醇的浓度以及冻融循环次数对甲硝唑释放率的影响。研究结果表明，羧甲基罗望子多糖的浓度以及羧甲基罗望子多糖与聚乙烯醇浓度的交互作用对甲硝唑的释放有显著影响。计算得到的最佳参数为：羧甲基罗望子多糖浓度6.0%（w/v）、聚乙烯醇浓度8.53%（w/v）和冻融循环次数4次，由此得到的冷冻凝胶在6小时内的释放率为75.77%。通过傅里叶变换红外光谱和X射线衍射研究证实了冷冻凝胶的形成。热学研究表明冷冻凝胶具有较高的热稳定性。
