Joly-Amado Aurélie, Cansell Céline, Denis Raphaël G P, Delbes Anne-Sophie, Castel Julien, Martinez Sarah, Luquet Serge
Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA) UMR 8251 CNRS, F-75205 Paris, France.
Univ Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative (BFA) UMR 8251 CNRS, F-75205 Paris, France.
Best Pract Res Clin Endocrinol Metab. 2014 Oct;28(5):725-37. doi: 10.1016/j.beem.2014.03.003. Epub 2014 Apr 4.
The arcuate nucleus (ARC) of the hypothalamus is particularly regarded as a critical platform that integrates circulating signals of hunger and satiety reflecting energy stores and nutrient availability. Among ARC neurons, pro-opiomelanocortin (POMC) and agouti-related protein and neuropeptide Y (NPY/AgRP neurons) are considered as two opposing branches of the melanocortin signaling pathway. Integration of circulating signals of hunger and satiety results in the release of the melanocortin receptor ligand α-melanocyte-stimulating hormone (αMSH) by the POMC neurons system and decreases feeding and increases energy expenditure. The orexigenic/anabolic action of NPY/AgRP neurons is believed to rely essentially on their inhibitory input onto POMC neurons and second-orders targets. Recent updates in the field have casted a new light on the role of the ARC neurons in the coordinated regulation of peripheral organs involved in the control of nutrient storage, transformation and substrate utilization independent of food intake.
下丘脑弓状核（ARC）被特别视为一个关键平台，它整合反映能量储备和营养可利用性的饥饿和饱腹感循环信号。在ARC神经元中，促阿片-黑素细胞皮质素原（POMC）、刺鼠相关蛋白和神经肽Y（NPY/AgRP神经元）被认为是黑皮质素信号通路的两个相反分支。饥饿和饱腹感循环信号的整合导致POMC神经元系统释放黑皮质素受体配体α-黑素细胞刺激素（αMSH），从而减少进食并增加能量消耗。NPY/AgRP神经元的促食欲/合成代谢作用被认为主要依赖于它们对POMC神经元及其二级靶点的抑制性输入。该领域的最新进展为ARC神经元在独立于食物摄入的营养储存、转化和底物利用控制中涉及的外周器官协调调节中的作用提供了新的视角。
