Sun Xurui, Liu Binghan, Yuan Yuan, Rong Ying, Pang Rui, Li Qiu
Key Laboratory of Endocrine Glucose and Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Front Nutr. 2025 Mar 24;12:1484827. doi: 10.3389/fnut.2025.1484827. eCollection 2025.
Numerous animal and clinical studies have demonstrated that the arcuate nucleus of the hypothalamus, a central regulator of appetite, plays a significant role in modulating feeding behavior. However, current research primarily focuses on long-term dietary changes and their effects on the body, with limited investigation into neuroendocrine dynamics during individual meals across diverse populations. In contrast to long-term dietary adjustments, directives for dietary behavior during a specific meal are more actionable, potentially enhancing patient adherence and achieving better outcomes in dietary behavior interventions. This review aimed to explore the neural pathways and endocrine changes activated by gastrointestinal expansion and variations in blood nutrient levels during a single meal, with the goal of informing dietary behavior guidance.
大量的动物和临床研究表明，下丘脑弓状核作为食欲的中枢调节者，在调节进食行为中起着重要作用。然而，目前的研究主要集中在长期饮食变化及其对身体的影响上，对不同人群在每餐期间神经内分泌动态的研究有限。与长期饮食调整相比，特定一餐期间的饮食行为指导更具可操作性，可能会提高患者的依从性，并在饮食行为干预中取得更好的效果。本综述旨在探讨单次进餐期间胃肠道扩张和血液营养水平变化所激活的神经通路和内分泌变化，以期为饮食行为指导提供依据。
