Arjona-Sanchez Alvaro, Muñoz-Casares Cristobal, Ortega-Salas Rosa, Casado-Adam Angela, Sanchez-Hidalgo Juan Manuel, Rufián-Peña Sebastián
Department of Oncological Surgery, University Hospital Reina Sofia , Córdoba and.
Int J Hyperthermia. 2014 Sep;30(6):408-11. doi: 10.3109/02656736.2014.952251.
Traditionally, peritoneal carcinomatosis (PC) was regarded as an untreatable condition; however, the introduction of locoregional therapies combining cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) approximately two decades ago has changed this view. There is controversy, however, when a PC arises from pancreatic cancer. We have reported on an extraordinary case of an aggressive pseudomixoma peritonei arising from an invasive intraductal papillary mucinous neoplasm (IPMN) treated with complete cytoreduction and HIPEC. This combination of treatments has not been previously described. Moreover, a very long-term disease-free survival of up to 70 months has been achieved by this combined approach. This approach may provide some optimism for considerable life extension in selected patients who present with an aggressive peritoneal mucinous carcinomatosis of pancreatic origin considered suitable only for palliative care.
传统上，腹膜癌病（PC）被视为一种无法治疗的疾病；然而，大约二十年前引入的将细胞减灭术（CRS）和热灌注化疗（HIPEC）相结合的局部区域治疗方法改变了这一观点。然而，当PC由胰腺癌引起时，仍存在争议。我们报告了一例罕见病例，该病例为侵袭性导管内乳头状黏液性肿瘤（IPMN）引发的侵袭性腹膜假黏液瘤，通过完全细胞减灭术和HIPEC进行治疗。此前尚未描述过这种联合治疗方法。此外，通过这种联合方法已实现长达70个月的非常长期的无病生存期。对于某些仅被认为适合姑息治疗的、患有侵袭性胰腺源性腹膜黏液癌的特定患者，这种方法可能为显著延长生存期带来一些希望。
