强迫症中默认模式网络子系统的改变。
Default mode network subsystem alterations in obsessive-compulsive disorder.
机构信息
Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
出版信息
Br J Psychiatry. 2014 Nov;205(5):376-82. doi: 10.1192/bjp.bp.113.137380. Epub 2014 Sep 25.
BACKGROUND
Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results.
AIMS
To resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD.
METHOD
Comparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging.
RESULTS
Significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed.
CONCLUSIONS
Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.
背景
尽管强迫症（OCD）的神经生物学模型传统上强调皮质纹状体脑区的核心作用，但对默认模式网络完整性的研究引起了越来越多的关注，但结果却存在矛盾。
目的
通过检查 OCD 中默认模式网络子系统的完整性来解决这些不一致的发现。
方法
使用功能磁共振成像比较 46 名 OCD 患者和 46 名对照者 11 个默认模式网络成分的基于种子的静息状态功能连接。
结果
在 OCD 组中发现背内侧前额叶皮层自我子系统的连接明显降低，在控制药物状态和一生中情感障碍的历史后仍然显著。此外，观察到自我子系统与突显和注意力网络之间的连接增加。
结论
结果表明，强迫症患者表现出与健康个体中自我参照处理相关的神经网络异常，并表明需要检查该默认模式网络子系统与该障碍中其他大规模网络之间的动态相互作用。
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