Fan Jie, Zhong Mingtian, Gan Jun, Liu Wanting, Niu Chaoyang, Liao Haiyan, Zhang Hongchun, Yi Jinyao, Chan Raymond C K, Tan Changlian, Zhu Xiongzhao
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Medical Psychological Institute of Central South University, Changsha, Hunan 410011, China.
Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, Guangdong 510631, China.
J Affect Disord. 2017 Dec 1;223:106-114. doi: 10.1016/j.jad.2017.07.041. Epub 2017 Jul 20.
Default mode network (DMN), central executive network (CEN) and salience network (SN) are the three most important intrinsic networks of the human brain. Recent studies emphasized the importance of the "triple-network model" which illustrated the interactions within and between DMN, CEN and SN in the pathophysiology of psychiatric disorders. However, previous studies of obsessive-compulsive disorder (OCD) just explored the altered connectivity within these networks while neglected the coupling between them. Hence, the present study was designed to fill this research gap.
Resting-state functional magnetic resonance imaging (fMRI) data from 35 OCD patients and 32 healthy controls (HCs) were acquired. Independent component analysis (ICA) was used to extract sub-networks of the DMN, CEN, and SN. Functional connectivity (FC) values within and between these networks were measured.
OCD patients had increased FC within several DMN, CEN, and SN subsystems. In addition, OCD patients demonstrated aberrant functional interactions between the SN and anterior DMN (aDMN) as well as between the SN and the dorsal CEN (dCEN), and the interaction between the SN and dCEN significantly correlated with trait anxiety level in the OCD group.
Lack of the assessments of cognitive functions is the main limitation of the present study.
Not only impaired coupling within the brain core intrinsic large-scale networks, but also coupling between large-scale neurocognitive networks, which reflect the difficulties in switching between task-negative and task-positive processing modes are involved in the neurobiological mechanism of OCD.
默认模式网络（DMN）、中央执行网络（CEN）和突显网络（SN）是人类大脑中三个最重要的内在网络。最近的研究强调了“三重网络模型”的重要性，该模型阐述了DMN、CEN和SN内部及之间在精神疾病病理生理学中的相互作用。然而，先前关于强迫症（OCD）的研究仅探讨了这些网络内部连接性的改变，而忽略了它们之间的耦合。因此，本研究旨在填补这一研究空白。
获取了35名强迫症患者和32名健康对照者（HCs）的静息态功能磁共振成像（fMRI）数据。采用独立成分分析（ICA）提取DMN、CEN和SN的子网络。测量了这些网络内部及之间的功能连接（FC）值。
强迫症患者在几个DMN、CEN和SN子系统内的FC增加。此外，强迫症患者在SN与前DMN（aDMN）之间以及SN与背侧CEN（dCEN）之间表现出异常的功能相互作用，并且SN与dCEN之间的相互作用与强迫症组的特质焦虑水平显著相关。
缺乏认知功能评估是本研究的主要局限性。
强迫症的神经生物学机制不仅涉及大脑核心内在大规模网络内部的耦合受损，还涉及大规模神经认知网络之间的耦合，这反映了在任务负性和任务正性加工模式之间切换的困难。
