Kodentsova V M, Vrzhesinskaya O A, Beketova N A, Kosheleva O V, Sokol'nikov A A
Research Institute of Nutrition, the Russian Academy of Medical Sciences, Moscow, Russia,
Bull Exp Biol Med. 2014 Sep;157(5):608-11. doi: 10.1007/s10517-014-2626-6. Epub 2014 Sep 26.
A 5-fold decrease of the content of vitamin mixture in the ration and exclusion of vitamin E from this mixture over 4 weeks led to a significant growth delay in rats initially weighing 58.1±0.5 g, but was inessential for the growth rates of animals weighing 107.1±1.1 g. The decrease in the levels of vitamins A and B2 in the liver and of 25-hydroxyvitamin D in the plasma of younger rats was more significant, this indicating their higher sensitivity to alimentary vitamin deficit. The increase in vitamin content in the ration to 100% over 5 days led to a significant body weight increment but did not restore vitamin levels in the liver, restoring, however, plasma levels of vitamins E and 25-hydroxyvitamin D. Addition of 50% vitamin content of the vitamin mixture for controls to vitamin-deficient rations of older rats for 2 weeks improved the levels of vitamins B1 and B2, but was virtually inessential for the liver content of vitamins A and E. High dose (158-200%) vitamins in animals of both age groups repaired the deficit of all vitamins, except vitamin A, despite the fact that its doses were the highest. These results validate long-term vitamin consumption for repair of their deficit.
日粮中维生素混合物含量降低5倍且4周内从该混合物中排除维生素E，导致初始体重为58.1±0.5克的大鼠生长显著延迟，但对体重为107.1±1.1克的动物生长速率影响不大。幼鼠肝脏中维生素A和B2水平以及血浆中25-羟基维生素D水平的降低更为显著，这表明它们对膳食维生素缺乏更为敏感。在5天内将日粮中维生素含量提高到100%导致体重显著增加，但未恢复肝脏中的维生素水平，不过恢复了血浆中维生素E和25-羟基维生素D的水平。在老年大鼠的维生素缺乏日粮中添加相当于对照组维生素混合物50%的维生素，持续2周，改善了维生素B1和B2的水平，但对肝脏中维生素A和E的含量几乎没有影响。两个年龄组动物摄入高剂量（158 - 200%）的维生素，除维生素A外，修复了所有维生素的缺乏，尽管维生素A的剂量是最高的。这些结果证实了长期摄入维生素可修复其缺乏。
