Kogan E A, Vyshegorodtsev D V, Faizullina N M, Demura T A, Kuz'minov A M, Shelygin Yu A, Sukhikh G T
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2014 Sep;157(5):683-8. doi: 10.1007/s10517-014-2643-5. Epub 2014 Sep 26.
We propose a new surgical approach to the treatment of familial colorectal adenomatous polyposis implying preservation of a portion of the rectum with removed mucosa. For reconstruction of the rectum, allotransplantation of the mixed culture of fetal allogenic somatic cells of the intestinal epithelium and mesenchymal cells of various origin is used. The mechanisms of mucosa reparation were studied in 34 patients. Endoscopic, morphological, and immunohistochemical studies showed that cell transplantation considerably accelerated reparation of the mucosa in mucosectomized rectum. The proposed treatment of familial colorectal adenomatous polyposis allows delaying the development of rectal polyps and cancer for many years.
我们提出了一种治疗家族性腺瘤性息肉病的新手术方法，即保留部分直肠并切除其黏膜。对于直肠重建，采用了来自不同来源的胎儿同种异体肠上皮体细胞和间充质细胞混合培养物的同种异体移植。对34例患者的黏膜修复机制进行了研究。内镜、形态学和免疫组化研究表明，细胞移植显著加速了黏膜切除术后直肠黏膜的修复。所提出的家族性腺瘤性息肉病治疗方法可使直肠息肉和癌症的发展延缓多年。
