Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
J Neurogastroenterol Motil. 2014 Oct 30;20(4):447-57. doi: 10.5056/jnm14080. Epub 2014 Sep 26.
Patients with dyspepsia/functional dyspepsia (FD) show frequent overlapping of other gastrointestinal (GI) diseases, such as irri-table bowel syndrome, and non-GI diseases, in addition to internal subgroup overlapping. These overlap patients have more frequent or more severe symptoms, poorer health-related quality of life and higher somatization scores, and they are more like-ly to experience anxiety, depression or insomnia compared to non-overlap patients. The higher prevalence of overlap in patients with dyspepsia/FD is not by chance, indicating common pathogeneses, including visceral hypersensitivity, altered GI motility, in-fection, and stressful early life events. There are few clinical trials targeting overlap in patients with dyspepsia/FD, and no ther-apeutic strategy has been established. Further studies in this research area are needed. In this review, we describe the epidemi-ology, pathogenesis and treatment of overlap in patients with dyspepsia/FD.(J Neurogastroenterol Motil 2014;20:447-457).
消化不良/功能性消化不良（FD）患者除了内部亚组重叠外，还经常出现其他胃肠道（GI）疾病（如肠易激综合征）和非 GI 疾病的重叠。这些重叠患者的症状更频繁或更严重，健康相关生活质量更差，躯体化评分更高，与非重叠患者相比，更有可能经历焦虑、抑郁或失眠。消化不良/FD 患者重叠的高患病率并非偶然，表明存在共同的发病机制，包括内脏高敏性、胃肠道动力改变、感染和压力性早期生活事件。针对消化不良/FD 患者重叠的临床试验很少，也没有确立治疗策略。需要在这一研究领域开展进一步的研究。在这篇综述中，我们描述了消化不良/FD 患者重叠的流行病学、发病机制和治疗。（《神经胃肠病学与动力学期刊》2014 年；20:447-457）。
