Friesen Craig A, Rosen John M, Schurman Jennifer V
Division of Gastroenterology, Hepatology, and Nutrition, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.
Division of Developmental and Behavioral Sciences, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.
BMC Gastroenterol. 2016 Jul 25;16(1):75. doi: 10.1186/s12876-016-0495-3.
The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms.
The study was a retrospective review of 100 consecutive pediatric patients, age 8-17 years, diagnosed with FD. All had completed a standardized medical history including gastrointestinal and systemic symptoms as well as specific symptoms related to GERD and OBS. The frequency of overlap with IBS, GERD, and OBS were determined for the whole group and for those fulfilling adult FD subtype criteria. Individual symptoms were also compared by FD subtype.
Overlap IBS was present in 33 % of the FD patients. At least one GERD symptom was present in 74 % of patients with 41 % reporting heartburn. At least one OBS symptom was present in 44 % of patients with 29 % reporting urinary urgency. Other than pain, the most common reported gastrointestinal symptom was nausea (86 %). Systemic symptoms were common. Overlap syndromes/symptoms did not vary by FD subtype. Postprandial distress syndrome was associated with pain with eating, weight loss, and waking at night to have a stool.
FD is a heterogeneous condition in children and adolescents with significant variability in the presence of gastrointestinal and non-gastrointestinal symptoms and overlap syndromes. Varying symptom profiles need to be accounted for and analyzed in studies involving subjects with FD.
目的是评估功能性消化不良（FD）中肠易激综合征（IBS）、胃食管反流病（GERD）和膀胱过度活动症（OBS）的重叠频率，以及其他胃肠道和全身症状。此外，我们试图确定成人罗马III型FD亚型是否与重叠综合征或症状存在独特关联。
该研究是对100例连续诊断为FD的8至17岁儿科患者进行的回顾性分析。所有患者均完成了标准化病史，包括胃肠道和全身症状以及与GERD和OBS相关的特定症状。确定了整个研究组以及符合成人FD亚型标准患者中IBS、GERD和OBS的重叠频率。还按FD亚型比较了个体症状。
33%的FD患者存在IBS重叠。74%的患者至少有一项GERD症状，其中41%报告有烧心症状。44%的患者至少有一项OBS症状，其中29%报告有尿急症状。除疼痛外，最常见的胃肠道症状是恶心（86%）。全身症状也很常见。重叠综合征/症状在FD亚型之间没有差异。餐后不适综合征与进食时疼痛、体重减轻和夜间醒来排便有关。
FD在儿童和青少年中是一种异质性疾病，胃肠道和非胃肠道症状以及重叠综合征的存在具有显著变异性。在涉及FD患者的研究中，需要考虑并分析不同的症状特征。
