Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, Montevideo 11600, Uruguay.
Department of Physiology, School of Medicine, Montevideo 11300, Uruguay.
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:185-8. doi: 10.1016/j.pnpbp.2014.09.003. Epub 2014 Sep 26.
A study was carried out on the effects of unilateral microinjection of melanin-concentrating hormone (MCH) into the right locus coeruleus (LC) on the sleep-wake cycle in rats prepared for chronic sleep recordings. MCH 200 ng significantly augmented rapid-eye-movement sleep (REMS) time during the first, second and third 2-h of recording. Furthermore, MCH 100 ng induced a significant increase of REMS during the first 2-h period after treatment. The increment of the behavioral state was related to a greater number of REMS episodes. It is suggested that MCH deactivation of noradrenergic neurons located in the LC facilitates the occurrence of REMS.
一项研究观察了单侧微量注射黑色素聚集激素（MCH）到右侧蓝斑（LC）对准备进行慢性睡眠记录的大鼠睡眠-觉醒周期的影响。MCH200ng 显著增加了记录的前 2 小时、第 2 小时和第 3 小时的快速眼动睡眠（REMS）时间。此外，MCH100ng 在治疗后第 1 小时内显著增加了 REMS 时间。行为状态的增加与 REMS 发作次数的增加有关。这表明 LC 内去甲肾上腺素能神经元的 MCH 失活促进了 REMS 的发生。
