全髋关节置换术失败的遗传易感性：一项关于基质金属蛋白酶1基因多态性影响的病例对照研究。
Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism.
作者信息
Yan Yiguo, Hu Jianzhong, Lu Hongbin, Wang Wenjun
出版信息
Diagn Pathol. 2014 Sep 26;9:177. doi: 10.1186/s13000-014-0177-9.
BACKGROUND
Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening).
METHODS
The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls.
RESULTS
The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P=0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening.
CONCLUSION
The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility.
VIRTUAL SLIDES
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177.
背景
遗传因素在全髋关节置换术（THA）早期失败的病因中起重要作用，基质金属蛋白酶-1（MMP-1）基因多态性rs5854可能与之相关。本研究旨在揭示MMP-1 rs5854 C/T多态性与THA早期失败（无菌性松动）风险之间的可能关联。
方法
对63例在全髋关节置换术后10年内被诊断为无菌性松动的患者以及81例年龄和性别匹配的对照者进行MMP-1基因rs5854单核苷酸多态性（SNP）基因分型。
结果
THA失败患者中MMP-1 rs5854 C/T多态性的基因型频率分别为57.1%（CC）、28.6%（CT）和14.3%（TT），对照组分别为79.0%（CC）、17.3%（CT）和3.7%（TT）（P = 0.0099）。发现rs5854多态性与无菌性松动风险增加显著相关。
结论
结果表明rs5854 SNP与早期无菌性松动易感性风险增加有关。
虚拟切片
本文的虚拟切片可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177 。
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