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体位性和非体位性轻度阻塞性睡眠呼吸暂停患者心血管合并症与持续气道正压通气使用情况的比较

Comparison of cardiovascular co-morbidities and CPAP use in patients with positional and non-positional mild obstructive sleep apnea.

作者信息

Huang Yi-Chih, Lin Chun-Yao, Lan Chou-Chin, Wu Yao-Kuang, Lim Chor-Shen, Huang Chun-Yao, Huang Hsuan-Li, Yeh Kuan-Hung, Liu Yu-Chih, Yang Mei-Chen

机构信息

Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzuchi Hospital, the Buddhist Tzuchi Medical Foundation, Xindian Dist, New Taipei City, Taiwan.

出版信息

BMC Pulm Med. 2014 Sep 26;14:153. doi: 10.1186/1471-2466-14-153.

DOI:10.1186/1471-2466-14-153
PMID:25257571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4189203/
Abstract

BACKGROUND

This retrospective cohort study aimed to determine if there are differences in cardiovascular co-morbidities, blood pressure (BP) and continuous positive airway pressure (CPAP) use between patients with positional-dependent and nonpositional-dependent obstructive sleep apnea (OSA).

METHODS

Patients who were referred for overnight polysomnography for suspected OSA between 2007 and 2011 were screened. A total of 371 patients with OSA were included for analysis and divided into six groups according to positional-dependency and severity of OSA: positional mild (n = 52), positional moderate (n = 29), positional severe (n = 24), non-positional mild (n = 18), non-positional moderate (n = 70) and non-positional severe group (n = 178). The six groups were compared for anthropometric and polysomnographic variables, presence of cardiovascular co-morbidities, morning and evening BP and the changes between evening and morning BP, and CPAP device usage patterns.

RESULTS

Demographic and anthropometric variables showed non-positional severe OSA had poor sleep quality and higher morning blood pressures. Positional mild OSA had the lowest cardiovascular co-morbidities. Overall CPAP acceptance was 45.6%. Mild OSA patients had the lowest CPAP acceptance rate (10%), followed by moderate group (37.37%) and severe group (61.88%, P < 0.001). However, the significant difference in CPAP acceptance across OSA severity disappeared when the data was stratified by positional dependency.

CONCLUSIONS

This study found that positional mild OSA had less cardiovascular co-morbidities compared with subjects with positional severe OSA. Independent of posture, CPAP acceptance in patients with mild OSA was low, but CPAP compliance was similar in CPAP acceptors regardless of posture dependency of OSA. Since there are increasing evidences of greater cardiovascular risk for untreated mild OSA, improving CPAP acceptance among mild OSA patients may be clinically important regardless of posture dependency.

摘要

背景

这项回顾性队列研究旨在确定体位依赖性和非体位依赖性阻塞性睡眠呼吸暂停(OSA)患者在心血管合并症、血压(BP)和持续气道正压通气(CPAP)使用方面是否存在差异。

方法

对2007年至2011年间因疑似OSA而接受夜间多导睡眠图检查的患者进行筛查。共有371例OSA患者纳入分析,并根据体位依赖性和OSA严重程度分为六组:体位性轻度(n = 52)、体位性中度(n = 29)、体位性重度(n = 24)、非体位性轻度(n = 18)、非体位性中度(n = 70)和非体位性重度组(n = 178)。比较六组的人体测量和多导睡眠图变量、心血管合并症的存在情况、早晚血压以及早晚血压的变化,以及CPAP设备使用模式。

结果

人口统计学和人体测量变量显示,非体位性重度OSA睡眠质量差且晨起血压较高。体位性轻度OSA的心血管合并症最少。CPAP总体接受率为45.6%。轻度OSA患者的CPAP接受率最低(10%),其次是中度组(37.37%)和重度组(61.88%,P < 0.001)。然而,当按体位依赖性对数据进行分层时,OSA严重程度之间CPAP接受率的显著差异消失。

结论

本研究发现,与体位性重度OSA患者相比,体位性轻度OSA的心血管合并症较少。独立于体位,轻度OSA患者的CPAP接受率较低,但无论OSA的体位依赖性如何,CPAP接受者的CPAP依从性相似。由于越来越多的证据表明未经治疗的轻度OSA存在更大的心血管风险,因此提高轻度OSA患者对CPAP的接受率在临床上可能很重要,无论体位依赖性如何。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0e/4189203/a855bb45bfdd/12890_2013_589_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0e/4189203/a855bb45bfdd/12890_2013_589_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b0e/4189203/a855bb45bfdd/12890_2013_589_Fig1_HTML.jpg

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本文引用的文献

1
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2
Positive airway pressure device compliance of the patients with obstructive sleep apnea syndrome.阻塞性睡眠呼吸暂停综合征患者的气道正压装置顺应性。
Adv Clin Exp Med. 2013 Nov-Dec;22(6):809-15.
3
Obstructive sleep apnoea and cardiovascular complications: perception versus knowledge.阻塞性睡眠呼吸暂停与心血管并发症:认知与知识的差距。
Sleep Breath. 2022 Jun;26(2):595-604. doi: 10.1007/s11325-021-02421-0. Epub 2021 Jun 29.
4
Preliminary study on clinical characteristics of Chinese patients with positional obstructive sleep apnea.中国人因体位导致阻塞性睡眠呼吸暂停临床特征的初步研究
Sleep Breath. 2022 Mar;26(1):67-74. doi: 10.1007/s11325-021-02346-8. Epub 2021 Mar 30.
5
Assessment of Nocturnal Autonomic Cardiac Imbalance in Positional Obstructive Sleep Apnea. A Multiscale Nonlinear Approach.体位性阻塞性睡眠呼吸暂停夜间自主心脏失衡的评估:一种多尺度非线性方法
Entropy (Basel). 2020 Dec 12;22(12):1404. doi: 10.3390/e22121404.
6
The treatment of mild OSA with CPAP or mandibular advancement device and the effect on blood pressure and endothelial function after one year of treatment.经 CPAP 或下颌前伸装置治疗轻度阻塞性睡眠呼吸暂停以及治疗一年后对血压和血管内皮功能的影响。
J Clin Sleep Med. 2021 Feb 1;17(2):149-158. doi: 10.5664/jcsm.8822.
7
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8
Expert panel consensus recommendations for ambulatory blood pressure monitoring in Asia: The HOPE Asia Network.亚洲动态血压监测专家共识推荐意见:HOPE 亚洲网络。
J Clin Hypertens (Greenwich). 2019 Sep;21(9):1250-1283. doi: 10.1111/jch.13652.
9
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10
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Clin Exp Pharmacol Physiol. 2012 Dec;39(12):995-1003. doi: 10.1111/1440-1681.12024.
4
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5
Obstructive sleep apnea syndrome.阻塞性睡眠呼吸暂停综合征。
Eur J Intern Med. 2012 Oct;23(7):586-93. doi: 10.1016/j.ejim.2012.05.013. Epub 2012 Jun 24.
6
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Sleep Breath. 2013 May;17(2):771-9. doi: 10.1007/s11325-012-0764-5. Epub 2012 Aug 25.
7
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JAMA. 2012 May 23;307(20):2161-8. doi: 10.1001/jama.2012.4366.
8
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9
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10
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Sleep Med. 2012 Mar;13(3):263-8. doi: 10.1016/j.sleep.2011.07.016. Epub 2011 Dec 6.