Lobo Isabela, David Isabel A, Figueira Ivan, Campagnoli Rafaela R, Volchan Eliane, Pereira Mirtes G, de Oliveira Leticia
Instituto Biomédico, Universidade Federal Fluminense, Rua Hernani Pires de Mello, 101, Niterói 24210130, Brazil.
Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Avenida Venceslau Brás, 71, Rio de Janeiro 22290140, Brazil.
Biol Psychol. 2014 Dec;103:233-41. doi: 10.1016/j.biopsycho.2014.09.002. Epub 2014 Sep 27.
Despite the impressive progress in the biological research of posttraumatic stress disorder (PTSD), little is known about the neurobiological correlates of emotional reactions in healthy people with posttraumatic stress symptoms (PTSS). The present study investigated whether PTSS are related to the electrocortical processing of unpleasant pictures in a sample of undergraduate students. Participants were instructed to judge whether images were unpleasant or neutral while an EEG was taken. The late positive potential (LPP) to unpleasant relative to neutral was more positive for people with high PTSS than with low PTSS. Additionally, a temporospatial principal components analysis (PCA) for the whole sample identified positivities that were directly correlated with PTSS. These results provide evidence that brain reactivity to unpleasant cues would predict PTSS intensity and thus be a biomarker of PTSS severity.
尽管创伤后应激障碍（PTSD）的生物学研究取得了令人瞩目的进展，但对于有创伤后应激症状（PTSS）的健康人群情绪反应的神经生物学相关性却知之甚少。本研究调查了在一组本科生样本中，PTSS是否与对不愉快图片的皮层电活动处理有关。参与者在进行脑电图记录时，被要求判断图片是不愉快的还是中性的。与低PTSS者相比，高PTSS者对不愉快图片相对于中性图片的晚期正电位（LPP）更正。此外，对整个样本进行的颞空间主成分分析（PCA）确定了与PTSS直接相关的正电位。这些结果提供了证据，表明大脑对不愉快线索的反应性可以预测PTSS强度，因此是PTSS严重程度的一个生物标志物。
