Lapenta Leonardo, Frisullo Giovanni, Vollono Catello, Brunetti Valerio, Giannantoni Nadia Mariagrazia, Sandroni Claudio, Di Lella Giuseppe, Della Marca Giacomo
Institute of Neurology, Catholic University, Rome, Italy
Institute of Neurology, Catholic University, Rome, Italy.
Clin EEG Neurosci. 2015 Oct;46(4):335-9. doi: 10.1177/1550059414534418. Epub 2014 Sep 24.
Super-refractory status epilepticus (SE; ie, SE continuing or recurring despite 24 hours of general anesthesia) is a severe condition with high percentage of mortality and morbidity. Usually, this condition occurs because of serious brain damage; nevertheless, some patients develop super-refractory SE without identifiable etiology. Although not uncommonly encountered in neurointensive care, scientific data on this condition are still lacking in terms of treatment and prognosis. Herein, we report a case of super-refractory SE with recovery after 50 days, despite electroencephalographic (EEG) and magnetic resonance imaging (MRI) signs traditionally related to poor prognosis. A review of the literature on super-refractory SE is also presented.
超难治性癫痫持续状态（SE；即尽管接受了24小时全身麻醉仍持续或复发的SE）是一种严重疾病，死亡率和发病率很高。通常，这种情况是由于严重脑损伤所致；然而，一些患者在没有可识别病因的情况下发生超难治性SE。尽管在神经重症监护中并不罕见，但关于这种情况在治疗和预后方面的科学数据仍然缺乏。在此，我们报告一例超难治性SE病例，尽管脑电图（EEG）和磁共振成像（MRI）表现传统上与预后不良相关，但该患者在50天后康复。本文还对超难治性SE的文献进行了综述。
