Lo Schiavo Ada, Puca Rosa Valentina, Romano Francesca, Cozzi Roberto
Department of Dermatology, Second University of Naples, Naples, Italy.
Department of Dermatology, AORN "A Cardarelli", Naples, Italy.
Drug Des Devel Ther. 2014 Sep 18;8:1463-5. doi: 10.2147/DDDT.S66666. eCollection 2014.
Statins, also known as 3-hydroxy-3-methylglutaril-CoA reductase inhibitors, are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Although they are generally considered safe, some serious adverse effects, such as myositis, myopathy, and rhabdomyolysis can rarely occur. Furthermore, recent data from long-term follow-up on patients who have been taking statins for a long period of time suggest that prolonged exposure to statins may trigger autoimmune reactions. The exact mechanism of statin-induced autoimmune reactions is unclear. Statins, as proapoptotic agents, release nuclear antigen into the circulation and may induce the production of pathogenic autoantibodies. Herein we report the case of a 70 year-old man who developed a relapse of pemphigus erythematosus, a syndrome with features of both lupus erythematosus and pemphigus, after atorvastatin intake.
他汀类药物，也被称为3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂，是用于预防动脉粥样硬化和心血管事件的耐受性良好的药物。尽管它们通常被认为是安全的，但一些严重的不良反应，如肌炎、肌病和横纹肌溶解症很少会发生。此外，近期对长期服用他汀类药物患者的长期随访数据表明，长期接触他汀类药物可能引发自身免疫反应。他汀类药物诱发自身免疫反应的确切机制尚不清楚。他汀类药物作为促凋亡剂，可将核抗原释放到循环中，并可能诱导致病性自身抗体的产生。在此，我们报告一例70岁男性患者，在服用阿托伐他汀后，出现了红斑性天疱疮复发，该综合征具有红斑狼疮和天疱疮的特征。
