Sox2转录网络作为一种分子开关来调节神经干细胞的特性。
Sox2 transcription network acts as a molecular switch to regulate properties of neural stem cells.
作者信息
Shimozaki Koji
机构信息
Koji Shimozaki, Division of Functional Genomics, Center for Frontier Life Science, Nagasaki University, Nagasaki 852-8523, Japan.
出版信息
World J Stem Cells. 2014 Sep 26;6(4):485-90. doi: 10.4252/wjsc.v6.i4.485.
Abstract
Neural stem cells (NSCs) contribute to ontogeny by producing neurons at the appropriate time and location. Neurogenesis from NSCs is also involved in various biological functions in adults. Thus, NSCs continue to exert their effects throughout the lifespan of the organism. The mechanism regulating the core functional properties of NSCs is governed by intra- and extracellular signals. Among the transcription factors that serve as molecular switches, Sox2 is considered a key factor in NSCs. Sox2 forms a core network with partner factors, thereby functioning as a molecular switch. This review discusses how the network of Sox2 partner and target genes illustrates the molecular characteristics of the mechanism underlying the self-renewal and multipotency of NSCs.
摘要
神经干细胞（NSCs）通过在适当的时间和位置产生神经元来促进个体发育。成年后，神经干细胞的神经发生也参与各种生物学功能。因此，神经干细胞在生物体的整个生命周期中持续发挥作用。调节神经干细胞核心功能特性的机制受细胞内和细胞外信号控制。在作为分子开关的转录因子中，Sox2被认为是神经干细胞中的关键因子。Sox2与伙伴因子形成核心网络，从而发挥分子开关的作用。本综述讨论了Sox2伙伴基因和靶基因网络如何阐明神经干细胞自我更新和多能性机制的分子特征。
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