微小RNA在糖尿病肾病中的作用。
The role of microRNAs in diabetic nephropathy.
作者信息
Wu Hao, Kong Lili, Zhou Shanshan, Cui Wenpeng, Xu Feng, Luo Manyu, Li Xiangqi, Tan Yi, Miao Lining
机构信息
Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China ; Chinese-American Research Institute for Diabetic Complications at Wenzhou Medical University, Wenzhou 325035, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
出版信息
J Diabetes Res. 2014;2014:920134. doi: 10.1155/2014/920134. Epub 2014 Sep 1.
Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.
糖尿病肾病（DN）作为糖尿病的慢性并发症之一，是终末期肾病的主要原因。然而，该疾病的发病机制尚未完全明确。近年来，由于微小RNA（miRNA）在调节蛋白质编码基因转录后水平中起关键作用，而这些基因可能是疾病的关键致病因素，因此对miRNA的研究已成为一个热点。已发现几种miRNA参与DN的发病机制，而其他一些miRNA则显示出肾脏保护作用。因此，靶向参与DN的miRNA可能在该疾病的治疗中具有良好的前景。本综述的目的是总结与DN相关的miRNA，并为诊断策略和治疗干预提供潜在靶点。
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