Delespesse G, Sarfati M, Hofstetter H
Immunol Today. 1989 May;10(5):159-64. doi: 10.1016/0167-5699(89)90173-4.
The production of IgE antibodies is known to be regulated by isotype-specific mechanisms that are not antigen specific. During the last decade several studies have indicated that soluble factors with affinity for IgE (IgE-binding factors, IgE-BFs) may exert such a role by interacting with IgE-bearing B lymphocytes. In the human, some of these IgE-BFs appear to be identical to soluble CD23, a B-cell surface marker thought to be involved in the control of B-cell proliferation or differentiation. In this article, Guy Delespesse and colleagues summarize several new findings regarding the cellular origin, structure and function of IgE-BFs/sCD23.
已知IgE抗体的产生受同种型特异性机制调控，而非抗原特异性机制。在过去十年中，多项研究表明，对IgE具有亲和力的可溶性因子（IgE结合因子，IgE-BFs）可能通过与携带IgE的B淋巴细胞相互作用发挥这种作用。在人类中，其中一些IgE-BFs似乎与可溶性CD23相同，可溶性CD23是一种B细胞表面标志物，被认为参与B细胞增殖或分化的控制。在本文中，盖伊·德莱斯佩斯及其同事总结了关于IgE-BFs/可溶性CD23的细胞起源、结构和功能的几项新发现。
