1Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.
Int Rev Immunol. 2015 Jan;34(1):34-49. doi: 10.3109/08830185.2014.956358. Epub 2014 Sep 26.
Energy homeostasis is a hallmark of cell survival and maintenance of cell function. Here we focus on the impact of cellular energy metabolism on T-lymphocyte differentiation, activation, and function in health and disease. We describe the role of transcriptional and posttranscriptional regulation of lymphocyte metabolism on immune functions of T cells. We also summarize the current knowledge about T-lymphocyte adaptations to inflammation and hypoxia, and the impact on T-cell behavior of pathophysiological hypoxia (as found in tumor tissue, chronically inflamed joints in rheumatoid arthritis and during bone regeneration). A better understanding of the underlying mechanisms that control immune cell metabolism and immune response may provide therapeutic opportunities to alter the immune response under conditions of either immunosuppression or inflammation, potentially targeting infections, vaccine response, tumor surveillance, autoimmunity, and inflammatory disorders.
能量平衡是细胞存活和维持细胞功能的标志。在这里，我们重点关注细胞能量代谢对健康和疾病状态下 T 淋巴细胞分化、激活和功能的影响。我们描述了转录和转录后调节淋巴细胞代谢对 T 细胞免疫功能的作用。我们还总结了目前关于 T 淋巴细胞适应炎症和缺氧的知识，以及病理缺氧（如肿瘤组织、类风湿关节炎慢性炎症关节和骨再生过程中）对 T 细胞行为的影响。更好地了解控制免疫细胞代谢和免疫反应的潜在机制，可能为改变免疫抑制或炎症条件下的免疫反应提供治疗机会，从而潜在地针对感染、疫苗反应、肿瘤监测、自身免疫和炎症性疾病。
